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Merck
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安全信息

HPA002328

Sigma-Aldrich

Anti-MAOB antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

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别名:
Anti-Amine oxidase [flavin-containing] B, Anti-MAO-B, Anti-Monoamine oxidase type B
UNSPSC代码:
12352203
人类蛋白质图谱编号:
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

产品线

Prestige Antibodies® Powered by Atlas Antibodies

形式

buffered aqueous glycerol solution

种属反应性

mouse, human, rat

增强验证

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

技术

immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:200-1:500

免疫原序列

WRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGAPHR

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... MAOB(4129)

一般描述

Monoamine oxidase (MAO) is localized in the outer mitochondrial membrane. It exists in two forms MAOA and MAOB. It is expressed in specific zone of brain i.e. hypothalamus, hippocampus, brain stem and olfactory bulb.

免疫原

Amine oxidase [flavin-containing] B recombinant protein epitope signature tag (PrEST)

应用

Anti-MAOB antibody produced in rabbit has been used for immunostaining and immunohistochemistry.

生化/生理作用

MAOB (monoamine oxidase B) is involved in the oxidative metabolism of neurotransmitters and dietary amines, such as dopamine, neuroactive, vasoactive amines and the Parkinsonism-producing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). It forms H2O2 during dopamine metabolism. It is associated with the cause of Parkinson′s disease (PD).

特点和优势

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST82420

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

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M Nakatome et al.
Biochemical and biophysical research communications, 247(2), 452-456 (1998-06-27)
Monoamine oxidase (MAO), which exists in two forms (MAOA and MAOB), plays an important role in the oxidative metabolism of neurotransmitters such as dopamine, and has been implicated in the etiology of Parkinson's disease (PD). Individual variations in the activity
Seonmi Jo et al.
Nature medicine, 20(8), 886-896 (2014-06-30)
In Alzheimer's disease (AD), memory impairment is the most prominent feature that afflicts patients and their families. Although reactive astrocytes have been observed around amyloid plaques since the disease was first described, their role in memory impairment has been poorly
Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer?s Disease
Olsen M, et al.
Molecular Imaging and Biology : MIB : The Official Publication of the Academy of Molecular Imaging, 20(8) (2017)
Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson?s Disease
Heo JY, et al.
Current Biology, 30(2) (2020)
Chie Hashizume et al.
The Journal of veterinary medical science, 65(8), 893-898 (2003-09-03)
The role of monoamine oxidase has been shown to be related to some behavioral changes including aggression and cognitive dysfunction. In order to demonstrate the basic expression patterns of monoamine oxidase in the canine brain, we determined the full-length nucleotide

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