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H9523

Sigma-Aldrich

3-(2-氨乙酸)吲哚 盐酸盐

≥98%, powder, neurotransmitter

别名:

3-(2-氨基乙基)-5 -羟基吲哚 盐酸盐, 5-羟色胺, 5-羟色胺 盐酸盐

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About This Item

经验公式（希尔记法）:
C10H12N2O · HCl
CAS号:
153-98-0
分子量:
212.68
Beilstein:
3570963
MDL编号:
MFCD00012686
UNSPSC代码:
12352200
PubChem化学物质编号:
24278124
NACRES:
NA.77

产品名称

3-(2-氨乙酸)吲哚 盐酸盐, powder

方案

≥98%

质量水平

200

表单

powder

颜色

white to off-white

mp

149-154 °C (lit.)

溶解性

H2O: 17 mg/mL
0.1 M HCl: 22 mg/mL
ethanol: 5.3 mg/mL

储存温度

2-8°C

SMILES字符串

Cl[H].NCCc1c[nH]c2ccc(O)cc12

InChI

1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H

InChI key

MDIGAZPGKJFIAH-UHFFFAOYSA-N

基因信息

human ... HTR3A(3359)

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一般描述

血清素普遍存在于所有动物中。它在中枢和外周神经系统中(CAN/PNS)发挥多样功能，是一种激素和丝裂原分子，血清素由大脑中的轴突终末生产。动作电位引发血清素释放，在突触中扩散结合到突触后受体引起神经反应。血清素在发育、呼吸、体温调节、内分泌、心血管和胃肠道功能中起重要作用。还在睡眠觉醒周期、性、情绪、记忆、攻击性、痛觉、学习和认知等感知觉行为中发挥作用。血清素影响多种精神障碍，包括精神分裂、神经性厌食症、抑郁，还影响强迫症、惊恐发作和社交恐惧症等焦虑障碍。血清素水平变化与药物滥用、赌博、注意力缺陷障碍、强迫症和冲动性的冲动相关障碍或人格障碍有关。

应用

盐酸血清素用于：研究5-羟色胺受体拮抗剂调节肝脏球状体纤维化的机制，研究其对人胚胎肾脏细胞细胞外信号调节激酶(ERK)磷酸化的影响，用于结肠癌细胞系的transwell试验、愈伤试验和肿瘤同种异体移植试验

生化/生理作用

神经递质。

特点和优势

该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面， 请单击此处。

制备说明

溶液需新鲜配制。

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险声明

H301,H361

危险分类

Acute Tox. 3 Oral - Repr. 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
0000402828
0000399499
0000376658
0000376659
0000361022

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Can I store solutions of Product H9523, Serotonin hydrochloride?

    Solutions of this product are unstable.  We recommend preparing this solution fresh for each application.

  6. Is Product H9523, Serotonin hydrochloride, the neurotransmitter serotonin?

    This product is the neurotransmitter serotonin.  Other synonyms for this product are 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, and 5-Hydroxytryptamine hydrochloride.

  7. What are the storage conditions for Product H9523, Serotonin hydrochloride?

    This product is a powder and should be refrigerated at 2-8°C. We do not recommend storing solutions of this product.

  8. Has Product H9523, Serotonin hydrochloride, been cell culture tested?

    No. We do not test this product for cell culture suitability.

  9. What is the purity of Product H9523, Serotonin hydrochloride?

    This product must be at least 98% pure according to our specifications.  The purity for individual lots can be found on the certificate of analysis.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Soaleha Shams et al.
Behavioral neuroscience, 131(6), 492-504 (2017-12-01)
Social isolation can be used to study behavioral, neural, and hormonal mechanisms that regulate interactions in social animals. Although isolation effects have been reported in social mammals and various fish species, systematic studies with isolated zebrafish are rare. Here, the
Serotonin Receptors
Nichols David E and Nichols Charles D.
Chemical Reviews (2008)
Sara Redenšek Trampuž et al.
Scientific reports, 14(1), 1396-1396 (2024-01-17)
Non-alcoholic steatohepatitis (NASH) is a major health problem leading to liver fibrosis and hepatocellular carcinoma, among other diseases, and for which there is still no approved drug treatment. Previous studies in animal models and in LX-2 cells have indicated a
Vinay Kumar Sharma et al.
Research square (2023-02-16)
5-Hydroxy tryptamine receptor 1E (5-HTR1E) is reported to activate cAMP and ERK pathways via its ligands and binding partners, but the detailed mechanism underlying the serotonin induced 5-HTR1E signaling is still not known. In the present study, we determined the
I Lucki
Biological psychiatry, 44(3), 151-162 (1998-08-07)
The diverse array of behavioral effects of serotonin form the basis for understanding its potential role as an etiological marker in psychiatric disorders and for the successful pharmacologic intervention of drugs regulating serotonin neurotransmission in behavior. General theories of the
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商品

血清素合成及代谢

血清素（5-羟色胺）主要存在于三种主要细胞类型中：i）中杻神经系统（CNS）和肠肌间神经丛中的血清素能神经元，ii）胃肠道粘膜中的肠嗜铬细胞，和iii）血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶（MAO）进行，它以两种分子亚型存在，分别称为MAO-A和MAO-B。

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

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