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H9523

Sigma-Aldrich

3-(2-氨乙酸)吲哚 盐酸盐

powder

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别名:
3-(2-氨基乙基)-5 -羟基吲哚 盐酸盐, 5-羟色胺, 5-羟色胺 盐酸盐
经验公式（希尔记法）:
C10H12N2O · HCl
CAS号:
153-98-0
分子量:
212.68
Beilstein:
3570963
MDL编号:
MFCD00012686
UNSPSC代码:
12352200
PubChem化学物质编号:
24278124
NACRES:
NA.77

检测方案

≥98%

质量水平

200

形式

powder

颜色

white to off-white

mp

149-154 °C (lit.)

溶解性

H2O: 17 mg/mL
0.1 M HCl: 22 mg/mL
ethanol: 5.3 mg/mL

储存温度

2-8°C

SMILES字符串

Cl[H].NCCc1c[nH]c2ccc(O)cc12

InChI

1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H

InChI key

MDIGAZPGKJFIAH-UHFFFAOYSA-N

基因信息

human ... HTR3A(3359)

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一般描述

Serotonin is a ubiquitous molecule found in all animals. It shows diverse effects in the central and peripheral nervous system (CAN/PNS). Serotonin acts as a hormone and as a mitogen. It is produced in the axon terminal present in the brain. Action potential induces the release of serotonin that diffuses across the synapse to turn on the post-synaptic receptors. Serotonin plays a crucialrole in development, respiration, thermoregulation, endocrine, cardiovascular, and gastrointestinal functions. It also plays a role in sensory perceptional behaviors such as the sleep-wake cycle, sex, mood, memory, aggression, pain sensitivity, learning, and cognition. Serotonin impacts several psychiatric disorders such as schizophrenia, anorexia nervosa, depression, and a range of anxiety disorders such as obsessive-compulsive disorder, panic attacks, and social phobia. Variations in serotonin levels are associated withimpulse-related disorders or personalities like substance abuse, gambling, attention deficit disorder, obsessive-control, and aggression.

应用

Serotonin hydrochloride hasbeen used: to study the mechanisms of 5-hydroxytryptamine receptor antagonistsregulate fibrosis in liver spheroids, to study its effects on theextracellular-related-kinase (ERK) phosphorylation in human embryonic kidneycells, in transwell assay, wound healing assay and tumor allograft assay incolon carcinoma cell line

生化/生理作用

神经递质。

特点和优势

该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面， 请单击此处。

制备说明

溶液需新鲜配制。

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险声明

H301,H361

危险分类

Acute Tox. 3 Oral - Repr. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Can I store solutions of Product H9523, Serotonin hydrochloride?

    Solutions of this product are unstable.  We recommend preparing this solution fresh for each application.

  6. Is Product H9523, Serotonin hydrochloride, the neurotransmitter serotonin?

    This product is the neurotransmitter serotonin.  Other synonyms for this product are 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, and 5-Hydroxytryptamine hydrochloride.

  7. What are the storage conditions for Product H9523, Serotonin hydrochloride?

    This product is a powder and should be refrigerated at 2-8°C. We do not recommend storing solutions of this product.

  8. Has Product H9523, Serotonin hydrochloride, been cell culture tested?

    No. We do not test this product for cell culture suitability.

  9. What is the purity of Product H9523, Serotonin hydrochloride?

    This product must be at least 98% pure according to our specifications.  The purity for individual lots can be found on the certificate of analysis.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Soaleha Shams et al.
Behavioral neuroscience, 131(6), 492-504 (2017-12-01)
Social isolation can be used to study behavioral, neural, and hormonal mechanisms that regulate interactions in social animals. Although isolation effects have been reported in social mammals and various fish species, systematic studies with isolated zebrafish are rare. Here, the
Sara Redenšek Trampuž et al.
Scientific reports, 14(1), 1396-1396 (2024-01-17)
Non-alcoholic steatohepatitis (NASH) is a major health problem leading to liver fibrosis and hepatocellular carcinoma, among other diseases, and for which there is still no approved drug treatment. Previous studies in animal models and in LX-2 cells have indicated a
Serotonin Receptors
Nichols David E and Nichols Charles D.
Chemical Reviews (2008)
Vinay Kumar Sharma et al.
Research square (2023-02-16)
5-Hydroxy tryptamine receptor 1E (5-HTR1E) is reported to activate cAMP and ERK pathways via its ligands and binding partners, but the detailed mechanism underlying the serotonin induced 5-HTR1E signaling is still not known. In the present study, we determined the
I Lucki
Biological psychiatry, 44(3), 151-162 (1998-08-07)
The diverse array of behavioral effects of serotonin form the basis for understanding its potential role as an etiological marker in psychiatric disorders and for the successful pharmacologic intervention of drugs regulating serotonin neurotransmission in behavior. General theories of the
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