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形式
powder
质量水平
颜色
light tan
mp
248-250 °C (lit.)
溶解性
alcohol: 20 mg/mL
H2O: soluble
储存温度
2-8°C
SMILES字符串
Cl[H].NCCc1ccc(O)c(O)c1
InChI
1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H
InChI key
CTENFNNZBMHDDG-UHFFFAOYSA-N
基因信息
human ... ADRB1(153)
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一般描述
多巴胺（DA）可作为中枢神经系统中的神经递质。它是由氨基酸L-酪氨酸制成的一种儿茶酚胺。它还可作为肾上腺髓质囊泡中的一种激素，从而对心跳速率和血压进行控制。含DA神经元的缺失与帕金森症相关。
应用
盐酸多巴胺已用于：
- 研究白对虾 Litopenaeus vannamei中多巴胺介导的生理反应的瞬时调节。
- 研究多巴胺介导的罗氏虾（Macrobrachium rosenbergii）对格氏乳球菌的免疫易感性的变化。
- 在亨廷顿舞蹈病的体外模型中，研究多巴胺诱导的氧化应激和变异亨廷顿蛋白（mHtt）毒性与自噬途径激活之间的分子联系
- 在以耐甲氧西林金黄色葡萄球菌（MRSA）为目标的抗微生物测试中，作为生物膜相中前酚氧化酶级联反应（PPO）的底物。
- 添加至培养基中以研究其对 H. contortus雌性蠕虫的作用。
特点和优势
该化合物是神经科学研究的特色产品。点击此处以了解更多的神经科学特色产品。可访问sigma.com/discover-bsm了解更多关于用于其他研究领域生物活性小分子。
注意
光敏感
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Natalia Del Campo et al.
Biological psychiatry, 69(12), e145-e157 (2011-05-10)
Through neuromodulatory influences over fronto-striato-cerebellar circuits, dopamine and noradrenaline play important roles in high-level executive functions often reported to be impaired in attention-deficit/hyperactivity disorder (ADHD). Medications used in the treatment of ADHD (including methylphenidate, dextroamphetamine and atomoxetine) act to increase
Rafael Franco et al.
Biomedicines, 9(2) (2021-01-28)
Dopamine is derived from an amino acid, phenylalanine, which must be obtained through the diet. Dopamine, known primarily to be a neurotransmitter involved in almost any higher executive action, acts through five types of G-protein-coupled receptors. Dopamine has been studied
Y Luo et al.
The Journal of biological chemistry, 273(6), 3756-3764 (1998-03-07)
Dopamine (DA) is a neurotransmitter, but it also exerts a neurotoxic effect under certain pathological conditions, including age-related neurodegeneration such as Parkinson's disease. By using both the 293 cell line and primary neonatal rat postmitotic striatal neuron cultures, we show
Peripheral Dopamine Controlled by Gut Microbes Inhibits Invariant Natural Killer T Cell-Mediated Hepatitis
Xue R, et al.
Frontiers in Immunology, 9, 2398-2398 (2018)
Dopamine depresses the immune ability and increases susceptibility to Lactococcus garvieae in the freshwater giant prawn, Macrobrachium rosenbergii.
Li JT et al.
Fish & Shellfish Immunology, 19, 269-269 (2005)
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DISCOVER Bioactive Small Molecules for Neuroscience
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