推荐产品
生物来源
human
质量水平
重组
expressed in HEK 293 cells
方案
>95% (SDS-PAGE)
表单
lyophilized powder
效能
≤0.6 ng/mL EC50
质量
endotoxin tested
分子量
dimer 14-19 kDa (glycosylated)
包装
pkg of 1 mg
pkg of 10 μg
pkg of 100 μg
制造商/商品名称
HumanZyme
技术
cell culture | mammalian: suitable
杂质
<1 EU/μg
UniProt登记号
储存温度
−20°C
基因信息
human ... IL4(3565)
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相关类别
一般描述
Interleukin-4 (IL-4) is a pleiotropic cytokine and a complex glycoprotein mapped to human chromosome 5q31.1. It is produced by mast cells, basophils and a subset of activated T cells.
生化/生理作用
Interleukin-4 (IL-4) interacts with interleukin 13 and is an interleukin-4 receptor ligand. It regulates IgE and IgG1 production by B cells. IL-4 favors glial and neuronal differentiation and regulates differentiation of naive cluster of differentiation CD4+ T cells to the T helper type 2 (TH2) cells. Polymorphism in the IL-4 gene is implicated in immune and inflammatory disorders. In cerebral infarction, IL-4 levels are elevated.
外形
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
制备说明
HumanKine Interleukin-4 (IL-4), expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 14-19 kDa due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
分析说明
The activity is determined by the dose-dependent simulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
法律信息
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
IL-4: role in disease and regulation of production.
P Choi et al.
Clinical and experimental immunology, 113(3), 317-319 (1998-09-16)
Interleukin 4 Receptor
Muscle and Exercise Physiology, 13(4) (1998)
Muscle as an endocrine organ
Muscle and Exercise Physiology, 13(4) (2019)
Robert Y L Zee et al.
Human molecular genetics, 13(4), 389-396 (2003-12-19)
Candidate gene polymorphisms related to inflammation, thrombosis and lipid metabolism have been implicated in the development of ischemic stroke. Using DNA samples collected at baseline in a prospective cohort of 14 916 initially healthy American men, we genotyped 92 polymorphisms
Neurogenesis, Inflammation, and Mental Health
Inflammation and Immunity in Depression, 13(4) (2018)
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