推荐产品
质量水平
检测方案
≥97.0%
bp
167 °C/0.8 mmHg (lit.)
mp
83-84 °C (lit.)
储存温度
−20°C
SMILES字符串
NCCc1c[nH]cn1
InChI
1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
InChI key
NTYJJOPFIAHURM-UHFFFAOYSA-N
基因信息
human ... CA1(759) , CA2(760) , HRH1(3269) , HRH2(3274) , HRH3(11255) , HRH4(59340)
rat ... Hrh1(24448) , Hrh3(85268)
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一般描述
组胺是由下丘脑后部神经元产生的神经递质。大脑中,组胺主要存在于灰质部分。
应用
组胺用于:
- 刺激调节型细胞分泌
- 在反应混合物中,活化血液,通过荧光测定法测定凝血酶(因子iia)活性
- 填充腔室腔侧,研究其对TJ相关屏障的影响以及声带上皮中TJ(紧密连接)标志物的表达
生化/生理作用
内源性 H1 和 H2 组胺受体激动剂;H1 的活化可以使 Ca2+ 移动;H2 的活化可促进神经元中腺苷酸环化酶的活性;活化一氧化氮合成酶;有效的血管舒张剂。
组胺参与先天免疫应答和获得性免疫应答,介导过敏和炎症。有助于肠道肌肉收缩。在过敏性休克过程中,组胺引起支气管收缩。组胺还参与分泌胃酸、控制上皮和内皮屏障。
警示用语:
Danger
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Journal of medicinal chemistry, 51(8), 2457-2467 (2008-03-25)
Using a previously reported flexible alignment model we have designed, synthesized, and evaluated a series of compounds at the human histamine H 4 receptor (H 4R) from which 2-(4-methyl-piperazin-1-yl)-quinoxaline ( 3) was identified as a new lead structure for H
Tight junction-related barrier contributes to the electrophysiological asymmetry across vocal fold epithelium
PLoS ONE, 7(3), e34017-e34017 (2012)
Nature chemical biology, 1(2), 98-103 (2006-01-13)
G protein-coupled receptors (GPCRs) constitute a large and functionally diverse family of transmembrane proteins. They are fundamental in the transfer of extracellular stimuli to intracellular signaling pathways and are among the most targeted proteins in drug discovery. The detailed molecular
Histamine in the nervous system
Physiological Reviews, 88(3), 1183-1241 (2008)
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