H6647
L-组氨醇 二盐酸盐
≥98% (TLC)
别名:
β-氨基咪唑-4-丙醇 二盐酸盐, (S)-2-氨基-3-(4-咪唑基)丙醇 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C6H11N3O · 2HCl
化学文摘社编号:
分子量:
214.09
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
216-482-2
MDL number:
Beilstein/REAXYS Number:
3914853
产品名称
L-组氨醇 二盐酸盐, ≥98 (TLC)
InChI key
FRCAFNBBXRWXQA-XRIGFGBMSA-N
InChI
1S/C6H11N3O.2ClH/c7-5(3-10)1-6-2-8-4-9-6;;/h2,4-5,10H,1,3,7H2,(H,8,9);2*1H/t5-;;/m0../s1
SMILES string
Cl[H].Cl[H].N[C@H](CO)Cc1c[nH]cn1
assay
≥98% (TLC)
form
powder
color
white to off-white
mp
198-201 °C (dec.) (lit.)
application(s)
cell analysis
Quality Level
Gene Information
human ... HRH1(3269)
mouse ... HRH1(15465)
rat ... HRH1(24448)
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Application
L-组氨醇二盐酸盐已用于：
- 作为尿液代谢物分析的试剂
- 制备 DT40 敲除细胞，在 1 mg/mL 组氨酸中选择细胞
- 在 HepG2 细胞中诱导氨基酸剥夺
Biochem/physiol Actions
组胺的前体；合成蛋白质的可逆抑制剂。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Fouzia Sadiq et al.
Nutrition & metabolism, 5, 5-5 (2008-02-14)
Intravenous infusions of glucose and amino acids increase both nitrogen balance and muscle accretion. We hypothesised that co-infusion of glucose (to stimulate insulin) and essential amino acids (EAA) would act additively to improve nitrogen balance by decreasing muscle protein degradation
R C Warrington
Biochemistry and cell biology = Biochimie et biologie cellulaire, 70(5), 365-375 (1992-05-01)
Human cancer chemotherapy is limited by two major problems: the failure of commonly used anticancer drugs to act against tumor cells in a specific manner and the ability of malignant cells to resist killing by antineoplastic agents. Experimentally, both of
David G Meckes et al.
Virology, 398(2), 208-213 (2010-01-07)
The conserved UL16 tegument protein of herpes simplex virus exhibits dynamic capsid-binding properties with a release mechanism that is triggered during initial virus attachment events. In an effort to understand the capsid association and subsequent release of UL16, we sought
Sebastian Alers et al.
Autophagy, 7(12), 1423-1433 (2011-10-26)
Under normal growth conditions the mammalian target of rapamycin complex 1 (mTORC1) negatively regulates the central autophagy regulator complex consisting of Unc-51-like kinases 1/2 (Ulk1/2), focal adhesion kinase family-interacting protein of 200 kDa (FIP200) and Atg13. Upon starvation, mTORC1-mediated repression
Ravi K Dinesh et al.
European journal of immunology, 50(3), 380-395 (2019-12-11)
Secondary diversification of the Ig repertoire occurs through somatic hypermutation (SHM), gene conversion (GCV), and class switch recombination (CSR)-three processes that are initiated by activation-induced cytidine deaminase (AID). AID targets Ig genes at orders of magnitude higher than the rest
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