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About This Item
经验公式（希尔记法）:
C15H18N2O
CAS号:
分子量:
242.32
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
生物来源
synthetic
质量水平
检测方案
≥98% (TLC)
形式
powder
溶解性
methanol: 10 mg/mL, clear, colorless
储存温度
2-8°C
SMILES字符串
C\C=C1/C2CC3=C(C=CC(=O)N3)C1(N)CC(C)=C2
InChI
1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+
InChI key
ZRJBHWIHUMBLCN-QDEBKDIKSA-N
基因信息
human ... BCHE(590)
rat ... Ache(83817)
一般描述
Huperzine A is an alkaloid derived from Chinese club moss Huperzia serrata.
应用
(±)-Huperzine A has been used in anti-acetylcholinesterase bioautographic assay.
生化/生理作用
Huperzine A is an effective acetylcholinesterase inhibitor and can cross the blood-brain barrier. Huperzine A is known to prevent cognitive defects, glutamate-induced nerve cell death.It is recognized for its use in the treatment of Alzheimer′s disease and organophosphate poisoning.
化学/物理抗性
Acetylcholinesterase inhibitor.
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
Yun Zhou et al.
Planta medica, 75(6), 568-574 (2009-02-14)
Three new saponins, bacopasides IX-XI (1- 3), together with their known analogues bacopaside I (4), bacopaside II (5), bacopasaponsin C (6), and bacopasaponsin D (7), were isolated from the whole plant of Bacopa monniera. Compounds 3, 4, and 6 showed
Coumarins from Peucedanum ostruthium. as Inhibitors of Acetylcholinesterase
Urbain A, et al.
Pharmaceutical biology, 43(8), 647-650 (2005)
Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat.
X C Tang et al.
Journal of neuroscience research, 24(2), 276-285 (1989-10-01)
The present study represents the first comprehensive investigation of the effect of huperzine A (HUP-A), a new cholinesterase inhibitor (ChEI) isolated from a Lycopodium species, upon acetylcholinesterase (AChE) activity, acetylcholine (ACh) levels and release, and cholinergic receptors in rat brain
Women's Health in Complementary and Integrative Medicine, 138-138 (2004)
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