H5777
(±)-石杉碱甲
synthetic, ≥98% (TLC)
别名:
(±)-Selagine
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关于此项目
经验公式（希尔记法）:
C15H18N2O
化学文摘社编号:
分子量:
242.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+
SMILES string
C\C=C1/C2CC3=C(C=CC(=O)N3)C1(N)CC(C)=C2
InChI key
ZRJBHWIHUMBLCN-QDEBKDIKSA-N
biological source
synthetic
assay
≥98% (TLC)
form
powder
solubility
methanol: 10 mg/mL, clear, colorless
storage temp.
2-8°C
Quality Level
Gene Information
human ... BCHE(590)
rat ... Ache(83817)
General description
Huperzine A is an alkaloid derived from Chinese club moss Huperzia serrata.
Application
(±)-Huperzine A has been used in anti-acetylcholinesterase bioautographic assay.
Biochem/physiol Actions
Huperzine A is an effective acetylcholinesterase inhibitor and can cross the blood-brain barrier. Huperzine A is known to prevent cognitive defects, glutamate-induced nerve cell death.It is recognized for its use in the treatment of Alzheimer′s disease and organophosphate poisoning.
Features and Benefits
Acetylcholinesterase inhibitor.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Women's Health in Complementary and Integrative Medicine, 138-138 (2004)
Coumarins from Peucedanum ostruthium. as Inhibitors of Acetylcholinesterase
Urbain A, et al.
Pharmaceutical biology, 43(8), 647-650 (2005)
Yun Zhou et al.
Planta medica, 75(6), 568-574 (2009-02-14)
Three new saponins, bacopasides IX-XI (1- 3), together with their known analogues bacopaside I (4), bacopaside II (5), bacopasaponsin C (6), and bacopasaponsin D (7), were isolated from the whole plant of Bacopa monniera. Compounds 3, 4, and 6 showed
Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat.
X C Tang et al.
Journal of neuroscience research, 24(2), 276-285 (1989-10-01)
The present study represents the first comprehensive investigation of the effect of huperzine A (HUP-A), a new cholinesterase inhibitor (ChEI) isolated from a Lycopodium species, upon acetylcholinesterase (AChE) activity, acetylcholine (ACh) levels and release, and cholinergic receptors in rat brain
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