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Merck
CN

H5136

Sigma-Aldrich

氢吗啡酮 盐酸盐

别名:

(5α)-4,5-Epoxy-3-hydroxy-17-methyl-morphinan-6-one hydrochloride, Hydromorphone HCl

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About This Item

经验公式(希尔记法):
C17H19NO3 · HCl
CAS号:
分子量:
321.80
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

药品控制

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

技术

HPLC: suitable
gas chromatography (GC): suitable

溶解性

H2O: >10 mg/mL

应用

forensics and toxicology
veterinary

SMILES字符串

OC1=C(O2)C3=C(C[C@@H]4[C@@]5([H])[C@@]3([C@]2([H])C(CC5)=O)CCN4C)C=C1.[H]Cl

InChI

1S/C17H19NO3.ClH/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;/h2,4,10-11,16,19H,3,5-8H2,1H3;1H/t10-,11+,16-,17-;/m0./s1

InChI key

XHILEZUETWRSHC-NRGUFEMZSA-N

基因信息

human ... OPRM1(4988)

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生化/生理作用

Narcotic opiate analgesic; μ opioid receptor agonist.

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

危险分类

Acute Tox. 4 Oral - STOT SE 3

靶器官

Central nervous system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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H M Korani et al.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T, 28(6), 409-416 (2015-10-10)
Evaluate variability associated with assessing changes in the position of uncemented femoral stems. Stem level, canal fill, stem angle, and version angle were measured on craniocaudal horizontal beam (CCHB) and open leg lateral (OLL) radiographic projections of the femur of
D L Cichewicz et al.
The Journal of pharmacology and experimental therapeutics, 289(2), 859-867 (1999-04-24)
The antinociceptive effects of various mu opioids given p.o. alone and in combination with Delta-9-tetrahydrocannabinol (Delta9-THC) were evaluated using the tail-flick test. Morphine preceded by Delta9-THC treatment (20 mg/kg) was significantly more potent than morphine alone, with an ED50 shift
E M Costa et al.
Life sciences, 50(1), 73-81 (1992-01-01)
SH-SY5Y (human neuroblastoma) cultured cells, known to have mu-opioid receptors, have been used to assess and compare the ability of eight representative mu-selective compounds from diverse opioid families to recognize and activate these receptors. A wide range of receptor affinities
P Sacerdote et al.
British journal of pharmacology, 121(4), 834-840 (1997-06-01)
1. Although it is well known that morphine induces significant immunosuppression, the potential immunosuppressive activity of morphine derived drugs commonly used in the treatment of pain (codeine, hydromorphone, oxycodone) has never been evaluated. 2. We evaluated in the mouse the

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