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安全信息

H4126

Sigma-Aldrich

醋酸氢化可的松

≥98% (HPLC)

别名:

11β,17α,21-三羟基-4-孕烯-3,20-二酮 21-乙酸酯, 17-α-羟基皮质甾酮乙酸酯, 17-羟基皮质甾酮 21-乙酸酯, 21-乙酰氧基-4-孕烯-11β,17α-二醇-3,20-二酮, 4-孕烯-11β,17α,21-三醇-3,20-二酮 21-乙酸酯

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About This Item

经验公式（希尔记法）:
C23H32O6
CAS号:
50-03-3
分子量:
404.50
Beilstein:
2066841
EC 号:
200-004-4
MDL编号:
MFCD00037714
UNSPSC代码:
12352200
PubChem化学物质编号:
24895620
NACRES:
NA.77

无菌性

non-sterile

质量水平

100

方案

≥98% (HPLC)

表单

powder

技术

permeability assay: suitable

mp

223 °C (dec.) (lit.)

运输

ambient

储存温度

room temp

SMILES字符串

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChI key

ALEXXDVDDISNDU-JZYPGELDSA-N

基因信息

human ... NR3C1(2908) , SERPINA6(866)

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一般描述

Hydrocortisone 21-acetate is an adrenocortical steroid. Hydrocortisone acts as an immunosuppressive drug and might suppress systemic inflammatory responses. It is used to treat rheumatoid arthritis and adrenal insufficiency. It also functions as an antiallergic agent.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360Df,H373

危险分类

Repr. 1B - STOT RE 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
MKCH5605
MKCJ6200
MKBW7364V
MKBT0288V
025K1123

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Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production
Attur MG, et al.
Inflammation Research, 49(1), 20-26 (2000)
Holger P Behrsing et al.
Toxicological sciences : an official journal of the Society of Toxicology, 131(2), 470-479 (2012-11-13)
The anticancer drug (2-[4-amino-3-methylphenyl]-5-fluorobenzothiazole lysylamide dihydrochloride) (NSC 710305, Phortress) is a metabolically activated prodrug that causes DNA adduct formation and subsequent toxicity. Preclinically, it was found that hepatic, bone marrow, and pulmonary toxicity presented challenges to developing this drug. An
Hydrocortisone and cortisone injected into arthritic joints: comparative effects of and use of hydrocortisone as a local antiarthritic agent
Hollander JL, et al.
Journal of the American Medical Association, 147(17), 1629-1635 (1951)
Adrenal insufficiency in patients with cirrhosis and septic shock: effect of treatment with hydrocortisone on survival
Fernandez J, et al.
Hepatology, 44(5), 1288-1295 (2006)
The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies, 20-26 (2014)
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