H3911
L-组氨酸
别名:
(S)-2-氨基-3-(4-咪唑基)丙酸, NSC 137773
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关于此项目
经验公式（希尔记法）:
C6H9N3O2
化学文摘社编号:
分子量:
155.15
UNSPSC Code:
12352209
NACRES:
NA.26
eCl@ss:
32160406
EC Number:
200-745-3
Beilstein/REAXYS Number:
84088
MDL number:
InChI
1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
SMILES string
N[C@@H](Cc1c[nH]cn1)C(O)=O
InChI key
HNDVDQJCIGZPNO-YFKPBYRVSA-N
biological source
non-animal source
assay
≥98.5%
form
crystalline powder
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, heavy metals, trace metals, residual solvents, tested
mp
282 °C (dec.) (lit.)
solubility
H2O: 50 mg/mL
suitability
suitable for manufacturing use
application(s)
pharmaceutical (small molecule)
foreign activity
cytotoxicity, tested
Quality Level
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General description
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我们用于生物制药加工的SAFC® 系列优质原料经过严格的质量控制流程，配合记录文件和技术专长帮助我们的客户达到M-Clarity Program规定的要求。
M-Clarity Program
我们全面的上游工艺化学品系列不仅为生物制药生产商提供生产传统和创新治疗药物所需的优质原料，而且帮助他们更快地将产品投放市场并简化监管问题。请相信我们能够为您带来透明的供应链和可靠的全球采购能力，以最佳的法规支持和服务简化您的产品认证。
M-Clarity Program
我们全面的上游工艺化学品系列不仅为生物制药生产商提供生产传统和创新治疗药物所需的优质原料，而且帮助他们更快地将产品投放市场并简化监管问题。请相信我们能够为您带来透明的供应链和可靠的全球采购能力，以最佳的法规支持和服务简化您的产品认证。
Application
L-组氨酸是一种必需氨基酸。它用作细胞培养基组分，用于治疗性重组蛋白和单克隆抗体的商业生物制造。
Biochem/physiol Actions
组胺的前体,经组氨酸脱羧酶作用可生成组胺。
Legal Information
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Microbial cell factories, 7, 28-28 (2008-10-14)
The large-scale production of G-protein coupled receptors (GPCRs) for functional and structural studies remains a challenge. Recent successes have been made in the expression of a range of GPCRs using Pichia pastoris as an expression host. P. pastoris has a
Urszula Kosinska Eriksson et al.
Science (New York, N.Y.), 340(6138), 1346-1349 (2013-06-15)
Aquaporins are membrane channels that facilitate the flow of water across biological membranes. Two conserved regions are central for selective function: the dual asparagine-proline-alanine (NPA) aquaporin signature motif and the aromatic and arginine selectivity filter (SF). Here, we present the
Pawel Swietach et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(22), E2064-E2073 (2013-05-17)
Ca(2+) signaling regulates cell function. This is subject to modulation by H(+) ions that are universal end-products of metabolism. Due to slow diffusion and common buffers, changes in cytoplasmic [Ca(2+)] ([Ca(2+)]i) or [H(+)] ([H(+)]i) can become compartmentalized, leading potentially to
H M Golder et al.
Journal of dairy science, 97(8), 5131-5150 (2014-06-03)
Ruminal bacterial community composition (BCC) and its associations with ruminal fermentation measures were studied in dairy heifers challenged with combinations of grain, fructose, and histidine in a partial factorial study. Holstein-Friesian heifers (n=30) were randomly allocated to 5 triticale grain-based
Giorgio Zoppellaro et al.
Biopolymers, 91(12), 1064-1082 (2009-06-19)
Six-coordinated heme groups are involved in a large variety of electron transfer reactions because of their ability to exist in both the ferrous (Fe(2+)) and ferric (Fe(3+)) state without any large differences in structure. Our studies on hemes coordinated by
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