H2775
DL - 苏式 -β-羟基天冬氨酸
别名:
苏式 -2-氨基-3-羟基琥珀酸
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关于此项目
经验公式（希尔记法）:
C4H7NO5
化学文摘社编号:
分子量:
149.10
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352106
NACRES:
NA.32
EC Number:
224-299-4
MDL number:
InChI key
YYLQUHNPNCGKJQ-JCYAYHJZSA-N
InChI
1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m1/s1
SMILES string
N[C@H]([C@@H](O)C(O)=O)C(O)=O
storage temp.
−20°C
Quality Level
Gene Information
human ... GLUL(2752)
mouse ... GLUL(14645)
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Application
DL-苏氨酸-β-在插管 sprague dawley 大鼠中使用羟基天冬氨酸 (THA) 阻断谷氨酸盐转运。
General description
DL -苏式-β-羟基天冬氨酸 (THA) 是一种谷氨酸摄取抑制剂。
flash_point_f
Not applicable
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
A Hirata et al.
Brain research, 771(1), 37-44 (1998-02-12)
Excitotoxicity secondary to the loss of glutamate transporters (GluT) has been proposed as a possible pathogenetic mechanism for neuronal degeneration in amyotrophic lateral sclerosis. We therefore investigated whether prolonged in vivo pharmacologic inhibition of GluT would result in neuronal damage
Ewa Nagańska et al.
Folia neuropathologica, 48(1), 35-44 (2010-04-13)
Erythropoietin (EPO) is a chemokine hormone that is widely distributed throughout the body including nervous system. For last years its role as cytokine involved in many physiological processes out of the bone marrow has been suggested. Moreover, it plays a
Nina Bionda et al.
Amino acids, 42(1), 285-293 (2010-11-18)
A simple and practical general synthetic protocol towards orthogonally protected tHyAsp derivatives fully compatible with Fmoc solid-phase peptide synthetic methodology is reported. Our approach includes enantioresolution of commercially available D: ,L: -tHyAsp racemic mixture by co-crystallization with L: -Lys, followed
Tatiana Borisova et al.
Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology, 14(1), P81-P82 (2008-04-01)
Activity of high-affinity glutamate transporters was altered in brain nerve terminals under artificial gravity conditions. Blood platelets contain glutamate transporters and are able to uptake glutamate. The goal of the research was to analyze comparatively L-[14C]glutamate transport in neuronal and
Richelle A Hemendinger et al.
Neurotoxicity research, 13(1), 49-61 (2008-03-28)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting from the progressive loss of motor neurons in the spinal cord and brain. To date, clinically effective neuroprotective agents have not been available. The current study demonstrates for the first time
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