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安全信息

H2270

Sigma-Aldrich

氢化可的松琥珀酸酯 钠盐

powder, BioReagent, suitable for cell culture

别名:

11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate 钠盐, 氢化可的松 21-半琥珀酸酯 钠盐

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About This Item

经验公式（希尔记法）:
C25H33NaO8
CAS号:
125-04-2
分子量:
484.51
EC 号:
204-725-5
MDL编号:
MFCD00069472
UNSPSC代码:
12352209
PubChem化学物质编号:
24278463
NACRES:
NA.77
生物来源:
synthetic (organic)
表单:
powder
方案:
≥90% (HPLC)

生物来源

synthetic (organic)

质量水平

200

产品线

BioReagent

方案

≥90% (HPLC)

表单

powder

技术

cell culture | mammalian: suitable

溶解性

H2O: 50 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(COC(CCC([O-])=O)=O)=O)=C1.[Na+]

InChI

1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1

InChI key

HHZQLQREDATOBM-CODXZCKSSA-M

基因信息

human ... NR3C1(2908)

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相关类别

一般描述

用于上皮和内皮贴壁细胞培养的氢化可的松。

应用

Hydrocortisone 21-hemisuccinate sodium salt has been used as a supplement in Dulbecco′s modified Eagle medium/nutrient mixture F-12 (DMEM F12) for culturing oral squamous cell carcinoma (OSCC) cell lines and immortalized cone photoreceptor cell line.

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H361d

预防措施声明

P201 - P308 + P313

危险分类

Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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分析证书(COA)

Lot/Batch Number
0000393740
0000353088
0000335684
0000393740
0000335684

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Daniel P Collins et al.
Hepatic medicine : evidence and research, 13, 37-44 (2021-04-23)
The SARS-CoV-2 virus may have direct or indirect effects on other human organs beyond the respiratory system and including the liver, via binding of the spike protein. This study investigated the potential direct interactions with the liver by comparing the
Ying Yuan et al.
Clinical epigenetics, 12(1), 135-135 (2020-09-08)
Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is assembled by histones and non-histones into a chromatin-like cccDNA minichromosome in the nucleus. The cellular histone acetyltransferase GCN5, displaying succinyltransferase activity, is recruited onto cccDNA to modulate HBV transcription in
Eleonora Nucera et al.
European journal of endocrinology, 164(1), 139-140 (2010-10-22)
We present the case of a woman with 'empty sella syndrome' who experienced generalized urticaria after the administration of sodium succinate hydrocortisone in two episodes. The patient underwent an allergological evaluation (prick, intradermal, and patch tests) with hydrocortisone sodium succinate
Jian-Hua Shi et al.
Steroids, 75(12), 853-858 (2010-05-18)
Accumulating evidence suggests that adiponectin plays an important role in the genesis of obesity and insulin resistance. Although it has been shown that glucocortocoids (GC) inhibit adiponectin expression in vitro, there exist discrepant results in vivo. In this study, we
Andrew J Semark et al.
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 15(1), 63-66 (2013-02-26)
Bolus dose concentrations of hydrocortisone (50mg/mL) are reported to be incompatible with midazolam and ciprofloxacin in Y-site mixing studies. We evaluated the physical and chemical compatibility of low concentrations of hydrocortisone sodium succinate (1 mg/ mL) with midazolam (1 mg/mL
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