H2138
氯化六甲铵
solid (hygroscopic)
别名:
N,N,N,N′,N′,N′-六甲基-1,6-己二胺二氯化物, N,N,N,N′,N′,N′-六甲基六亚甲基二氯化铵, 氯化六甲双铵
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关于此项目
线性分子式:
(CH3)3N(Cl)(CH2)6N(Cl)(CH3)3
化学文摘社编号:
分子量:
273.29
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-465-1
Beilstein/REAXYS Number:
3714806
MDL number:
Form:
solid (hygroscopic)
产品名称
氯化六甲铵, solid (hygroscopic)
InChI key
PYIHTIJNCRKDBV-UHFFFAOYSA-L
InChI
1S/C12H30N2.2ClH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
SMILES string
[Cl-].[Cl-].C[N+](C)(C)CCCCCC[N+](C)(C)C
form
solid (hygroscopic)
color
white
solubility
H2O: soluble
ethanol: soluble
Gene Information
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Application
氯化六甲双铵已被用于阻断烟碱样受体对其激动剂的反应。它还被用于研究内脏神经元的机械灵敏性。
Biochem/physiol Actions
氯化六甲双铵优先阻断自主神经节上的烟碱受体，只有在高剂量时才能通过血脑屏障。烟碱乙酰胆碱受体（nAChR）负责认知功能。阻断该受体导致认知受损。nAChR拮抗剂用于研究受体功能丧失的效应。六甲铵对阻断nAChR具有外围作用。
General description
烟碱乙酰胆碱受体（nAChR）形成由四个不同亚基组成的配体门控离子通道。每个亚基包含一个细胞外氨基末端结构域（亲水性）和羧基末端结构域以及四个跨膜结构域。nAChR是一种变构和跨膜蛋白，位于神经肌肉接头处。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
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Hibberd TJ, et al.
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Oyola-Cintron J, et al.
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