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Merck
CN
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文件

G9284

Sigma-Aldrich

胍 盐酸盐 溶液

Colorless liquid, 7.8 - 8.3 M, pH- 4.5 - 5.5

别名:

亚氨基脲 盐酸盐, 盐酸胍, 胍盐酸盐

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About This Item

经验公式（希尔记法）:
CH5N3 · HCl
CAS号:
50-01-1
分子量:
95.53
Beilstein:
3591990
MDL编号:
MFCD00013026
UNSPSC代码:
12352107
PubChem化学物质编号:
24895369
NACRES:
NA.55

质量水平

200

形式

liquid

密度

1.18 g/mL at 25 °C (lit.)

SMILES字符串

Cl.NC(N)=N

InChI

1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H

InChI key

PJJJBBJSCAKJQF-UHFFFAOYSA-N

基因信息

human ... KCNA1(3736) , KCNA10(3744) , KCNA2(3737) , KCNA3(3738) , KCNA4(3739) , KCNA5(3741) , KCNA6(3742) , KCNA7(3743) , KCNB1(3745) , KCNB2(9312) , KCNC1(3746) , KCNC2(3747) , KCNC3(3748) , KCNC4(3749) , KCND1(3750) , KCND2(3751) , KCND3(3752) , KCNF1(3754) , KCNG1(3755) , KCNG2(26251) , KCNG3(170850) , KCNG4(93107) , KCNH1(3756) , KCNH2(3757) , KCNH3(23416) , KCNH4(23415) , KCNH5(27133) , KCNH6(81033) , KCNH7(90134) , KCNH8(131096) , KCNQ1(3784) , KCNQ2(3785) , KCNQ3(3786) , KCNQ4(9132) , KCNQ5(56479) , KCNS1(3787) , KCNS2(3788) , KCNS3(3790) , KCNV1(27012) , KCNV2(169522)

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相关类别

应用

盐酸胍溶液已用于：
  • 蛋白质变性
  • 对下丘脑、丘脑、前额叶皮层和脑干样本进行匀浆，提取总 β-淀粉样蛋白（Aβ）并进行 Aβ42 定量
  • 作为一种离液变性剂处理人类免疫缺陷病毒-1（HIV-1）样本，研究其对 HIV-1 敏感性的影响并测定蛋白质稳定性

生化/生理作用

盐酸胍（Gnd-HCl）是一种高效的离液剂（chaotropic agent），作为变性剂被广泛用于RNA分离、球蛋白变性和蛋白质复性研究。它是一种合适的样品缓冲剂，可用于亲和纯化的蛋白质复合物的快速有效的洗脱，以及之后的蛋白质消化步骤。GnHCl可用于提取富含细胞包基质（ECM）‐的组织，包括骨骼、软骨、韧带和肌腱中的蛋白质。Gnd-HCl不用于蛋白质组学实验，因为其在低摩尔浓度下会干扰胰蛋白酶活性并且在与十二烷基硫酸钠（SDS）结合时具有沉淀倾向。它适用于进行快速和单步亲和纯化质谱（AP-MS）实验。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Protein digestion is an integral part of the "shotgun" proteomics approach and commonly requires overnight incubation prior to mass spectrometry analysis. Quadruplicate "shotgun" proteomic analysis of whole yeast lysate demonstrated that Guanidine-Hydrochloride (Gnd-HCl) protein digestion can be optimally completed within
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