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生物来源
goat
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
形式
lyophilized powder
种属反应性
human
技术
neutralization: suitable
UniProt登记号
储存温度
−20°C
基因信息
human ... GDNF(2668)
一般描述
The antibody neutralizes the biological activity of recombinant human GDNF.
免疫原
recombinant human GDNF expressed in Escherichia coli.
生化/生理作用
Glial cell-derived neurotrophic factor is a potent neurotrophic factor that is important for the maintenance, regeneration and survival of specific neuronal cells including autonomic neurons, motoneurons, noradrenergic and seotonergic neurons. Additionally, it promotes the invasion and metastatic behavior of certain types of cancers by activating ERK, p38, JNK and AP-1 mediated cell signaling.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline
制备说明
Purified using protein G.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Mikko Airavaara et al.
Parkinsonism & related disorders, 18 Suppl 1, S143-S146 (2011-12-23)
Although initially thought to be important primarily in neural development, a number of trophic proteins have been found to have neuroprotective and neuroregenerative activity in the adult central nervous system, particularly for midbrain dopamine neurons (MDN). Neurorestoration is potentially feasible
Jing-Yuan Chuang et al.
Oral oncology, 49(12), 1103-1112 (2013-09-28)
Perineural invasion is a prominent clinical feature of various cancers, which causes difficulty in curative resection. Glial cell-derived neurotrophic factor (GDNF), a potent neurotrophic factor, plays an important role in the invasive and metastatic behavior of various cancers. The aim
Shelley J Allen et al.
Pharmacology & therapeutics, 138(2), 155-175 (2013-01-26)
Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival, maintenance and regeneration of specific neuronal populations in the adult brain. Depletion of these neurotrophic factors has been
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