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Merck
CN

G5918

Sigma-Aldrich

GR 113808

≥98% (HPLC), solid

别名:

1-[2-[(甲磺酰基)氨基]乙基]-4-哌啶基]甲基1-甲基-1H-吲哚-3-羧酸酯

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About This Item

经验公式(希尔记法):
C19H27N3O4S
分子量:
393.50
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

方案

≥98% (HPLC)

表单

solid

颜色

white to light pink

溶解性

DMSO: >20 mg/mL

创始人

GlaxoSmithKline

储存温度

2-8°C

SMILES字符串

Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c3ccccc13

InChI

1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3

InChI key

MOZPSIXKYJUTKI-UHFFFAOYSA-N

基因信息

应用

GR 113808已被用作5-羟色胺受体4(5-HT4R)阻断剂,以研究其对大鼠心室心肌细胞中钙(Ca2+)瞬变的影响。它也已被用作5-HT4R拮抗剂,以研究其对胚胎后斑马鱼从头肠神经发生的影响。

生化/生理作用

GR 113808是5-HT4血清素受体拮抗剂。

特点和优势

该化合物由 GlaxoSmithKline开发。想浏览其他制药公司开发的化合物和已批准药物/候选药物目录, 请单击此处

法律信息

根据Glaxo­Smith­Kline的协议出售用于研究目的

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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分析证书(COA)

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访问文档库

H Matsuyoshi et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 22(7), 806-813 (2010-02-12)
It was recently reported that some 5-HT(4)-receptor agonists increased neuronal numbers and length of neurites in enteric neurons developing in vitro from immunoselected neural crest-derived precursors. We aimed to explore a novel approach in vivo to reconstruct the enteric neural
J P Spencer et al.
Neuroscience, 129(1), 49-54 (2004-10-19)
5-HT(4) receptors are widely distributed in both peripheral and central nervous systems where they couple, via a G-protein, to the activation of adenylate cyclase. In the brain, the highest 5-HT(4) receptor densities are found in the limbic system, including the
Kurt A Krobert et al.
Naunyn-Schmiedeberg's archives of pharmacology, 371(6), 473-479 (2005-07-14)
Prucalopride is a gastrointestinal prokinetic drug that acts through 5-HT4 receptors, but its potential effects on cardiac atrial function are unknown. We investigated the effects of prucalopride on human right atrium, piglet left atrium, and piglet sinoatrial node. The effects
I Gribovskaja-Rupp et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24(5), 472-478 (2012-02-07)
Colonic dysfunction occurs after pelvic autonomic nerve damage. The enteric nervous system can compensate. We investigated the role of mucosal serotonin receptors, 5-HT(3) and 5-HT(4) , in the colonic motility restoration over 2 weeks after parasympathetic pelvic nerve transection in
A N James et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 17(1), 76-82 (2005-01-27)
Selective serotonin reuptake inhibitors (SSRIs) are increasingly used to treat a variety of disorders but have gastrointestinal side-effects. To determine the effects of the SSRI, fluoxetine, on gastric smooth muscle contractility. Fundic, antral, and pyloric circular muscle contractility of guinea

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