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G5918

GR 113808

Name: GR 113808
Brand: SIGMA

≥98% (HPLC), solid

别名:

1-[2-[（甲磺酰基）氨基]乙基]-4-哌啶基]甲基1-甲基-1H-吲哚-3-羧酸酯

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关于此项目

经验公式（希尔记法）:

C₁₉H₂₇N₃O₄S

化学文摘社编号:

144625-51-4

分子量:

393.50

NACRES:

NA.77

PubChem Substance ID:

24278311

UNSPSC Code:

12352200

MDL number:

MFCD00912901

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

200

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属性

Quality Level

200

assay

≥98% (HPLC)

form

solid

color

white to light pink

solubility

DMSO: >20 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c3ccccc13

InChI

1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3

InChI key

MOZPSIXKYJUTKI-UHFFFAOYSA-N

Gene Information

human ... HTR4(3360)
rat ... Htr3a(79246), Htr4(25324)

说明

Application

GR 113808已被用作5-羟色胺受体4（5-HT4R）阻断剂，以研究其对大鼠心室心肌细胞中钙（Ca²⁺）瞬变的影响。它也已被用作5-HT4R拮抗剂，以研究其对胚胎后斑马鱼从头肠神经发生的影响。

Biochem/physiol Actions

GR 113808是5-HT₄血清素受体拮抗剂。

Features and Benefits

该化合物由 GlaxoSmithKline开发。想浏览其他制药公司开发的化合物和已批准药物/候选药物目录，请单击此处。

Legal Information

根据GlaxoSmithKline的协议出售用于研究目的

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

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Upregulation of mucosal 5-HT3 receptors is involved in restoration of colonic transit after pelvic nerve transection.

I Gribovskaja-Rupp et al.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24(5), 472-478 (2012-02-07)

Colonic dysfunction occurs after pelvic autonomic nerve damage. The enteric nervous system can compensate. We investigated the role of mucosal serotonin receptors, 5-HT(3) and 5-HT(4) , in the colonic motility restoration over 2 weeks after parasympathetic pelvic nerve transection in

Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors: comparison with recombinant human 5-HT4 splice variants.

Kurt A Krobert et al.

Naunyn-Schmiedeberg's archives of pharmacology, 371(6), 473-479 (2005-07-14)

Prucalopride is a gastrointestinal prokinetic drug that acts through 5-HT4 receptors, but its potential effects on cardiac atrial function are unknown. We investigated the effects of prucalopride on human right atrium, piglet left atrium, and piglet sinoatrial node. The effects

5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice.

M Cachard-Chastel et al.

British journal of pharmacology, 150(7), 883-892 (2007-02-28)

A strategy to treat Alzheimer's disease (AD) is to increase the soluble form of amyloid precursor protein (sAPPalpha), a promnesic protein, in the brain. Because strong evidence supports beneficial effects of 5-hydroxytryptamine 5-HT(4) receptor agonists in memory and learning, we

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全球贸易项目编号

货号	GTIN
G5918-50MG	04061832082240
G5918-10MG	04061832091006