产品名称
抗胶质纤维酸性蛋白 兔抗, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
flow cytometry: 1:200-1:500
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GFAP(2670)
mouse ... Gfap(14580)
rat ... Gfap(24387)
Application
兔多克隆抗 GFAP 抗体用于标记神经胶质纤维酸性蛋白，以通过蛋白质印迹和免疫组化（IHC）技术进行检测和定量。它用作确定神经胶质纤维酸性蛋白在细胞：细胞通讯、有丝分裂和细胞结构中的作用的探针。已证明抗 GFAP 可用于在正常的中枢神经系统组织、某些肿瘤和神经胶质抗原的转移中进行 GFAP 的免疫细胞化学定位，以及对培养的哺乳动物细胞进行免疫荧光标记。
Biochem/physiol Actions
兔多克隆抗神经胶质纤维酸性蛋白可识别人、小鼠和大鼠的 GFAP。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
具有 10 nm 直径特征的中间丝（IFs）是一类由超微结构，免疫学和生化标准定义的分子异质细胞骨架丝。中间丝与细胞的其他细胞骨架成分（即微管和微丝）明显不同，并且是大多数真核细胞的组成部分。在中枢神经系统的星形胶质细胞和上皮细胞中发现了胶质纤维酸性蛋白（GFAP）（分子量为 50 kDa）。它存在于星状细胞、软骨细胞、骨细胞、角质形成细胞、Leydig 细胞和成纤维细胞等其他各种细胞类型中。GFAP 参与有丝分裂以及细胞间相互作用和通讯。该基因的突变导致亚历山大病，这是中枢神经系统中罕见的星形胶质细胞疾病。
Immunogen
合成肽，对应于人 GFAP 的内部 C 端序列。
Physical form
溶于含有 0.02％ 叠氮化钠的磷酸盐缓冲液中。
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Maha Saber et al.
Journal of neurotrauma, 34(2), 423-435 (2016-03-16)
Traumatic brain injury (TBI) affects 1.7 million persons annually in the United States (Centers for Disease Control and Prevention). There is increasing evidence that persons exposed to TBI have increased risk of the development of multiple neurodegenerative conditions, including Alzheimer
Christopher G Dengler et al.
Scientific reports, 7, 42090-42090 (2017-02-22)
In a mouse model of temporal lobe epilepsy, multicellular calcium imaging revealed that disease emergence was accompanied by massive amplification in the normally sparse, afferent stimulation-induced activation of hippocampal dentate granule cells. Patch recordings demonstrated reductions in local inhibitory function
Jesús Agulla et al.
Theranostics, 4(1), 90-105 (2014-01-08)
The use of theranostics in neurosciences has been rare to date because of the limitations imposed on the free delivery of substances to the brain by the blood-brain barrier. Here we report the development of a theranostic system for the
Badrah Alghamdi et al.
Frontiers in neuroanatomy, 9, 49-49 (2015-06-25)
The extent to which NG-2(+) cells form a distinct population separate from astrocytes is central to understanding whether this important cell class is wholly an oligodendrocyte precursor cell (OPC) or has additional functions akin to those classically ascribed to astrocytes.
Smriti M Agrawal et al.
Brain : a journal of neurology, 136(Pt 6), 1760-1777 (2013-05-21)
Inflammatory perivascular cuffs are comprised of leucocytes that accumulate in the perivascular space around post-capillary venules before their infiltration into the parenchyma of the central nervous system. Inflammatory perivascular cuffs are commonly found in the central nervous system of patients
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持