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产品名称
抗胶质纤维酸性蛋白 兔抗, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~50 kDa
种属反应性
human, rat, mouse
1 of 4
此商品 | PHR1006 | S3889 | 85529 |
|---|---|---|---|
| form viscous liquid | form - | form powder | form powder |
| color colorless | color - | color white | color colorless |
| concentration 70 wt. % in H2O | concentration - | concentration - | concentration - |
| refractive index n20/D 1.46 | refractive index - | refractive index - | refractive index - |
| density 1.28 g/mL at 25 °C | density - | density - | density - |
一般描述
具有 10 nm 直径特征的中间丝（IFs）是一类由超微结构，免疫学和生化标准定义的分子异质细胞骨架丝。中间丝与细胞的其他细胞骨架成分（即微管和微丝）明显不同，并且是大多数真核细胞的组成部分。在中枢神经系统的星形胶质细胞和上皮细胞中发现了胶质纤维酸性蛋白（GFAP）（分子量为 50 kDa）。它存在于星状细胞、软骨细胞、骨细胞、角质形成细胞、Leydig 细胞和成纤维细胞等其他各种细胞类型中。GFAP 参与有丝分裂以及细胞间相互作用和通讯。该基因的突变导致亚历山大病，这是中枢神经系统中罕见的星形胶质细胞疾病。
特异性
兔多克隆抗神经胶质纤维酸性蛋白可识别人、小鼠和大鼠的 GFAP。
免疫原
合成肽，对应于人 GFAP 的内部 C 端序列。
应用
兔多克隆抗 GFAP 抗体用于标记神经胶质纤维酸性蛋白，以通过蛋白质印迹和免疫组化（IHC）技术进行检测和定量。它用作确定神经胶质纤维酸性蛋白在细胞：细胞通讯、有丝分裂和细胞结构中的作用的探针。已证明抗 GFAP 可用于在正常的中枢神经系统组织、某些肿瘤和神经胶质抗原的转移中进行 GFAP 的免疫细胞化学定位，以及对培养的哺乳动物细胞进行免疫荧光标记。
外形
溶于含有 0.02％ 叠氮化钠的磷酸盐缓冲液中。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
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