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Merck
CN
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文件

安全信息

G1272

Sigma-Aldrich

Gentamicin

liquid, non-animal origin, suitable for cell culture, BioReagent

别名:

庆大霉素 C, 正泰霉素

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About This Item

CAS号:
1405-41-0
EC 号:
215-778-9
MDL编号:
MFCD00270181
UNSPSC代码:
12352207
eCl@ss:
42020823
PubChem化学物质编号:
329799834
NACRES:
NA.76

product name

庆大霉素 溶液, 10 mg/mL in deionized water, liquid, 0.1 μm filtered, BioReagent, suitable for cell culture

生物来源

microbial

质量水平

300

无菌性

0.1 μm filtered

产品线

BioReagent

形式

liquid

效能

10-12 mg per mL

浓度

10 mg/mL in deionized water

技术

cell culture | mammalian: suitable

杂质

endotoxin, tested

颜色

colorless to light yellow

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H]2O.CN[C@@H]4[C@@H](O)[C@H](OC[C@]4(C)O)O[C@H]5[C@H](N)C[C@H](N)[C@@H](O[C@H]6O[C@@H](CC[C@H]6N)[C@@H](C)N)[C@@H]5O.CN[C@H](C)[C@@H]7CC[C@@H](N)[C@H](O7)O[C@@H]8[C@@H](N)C[C@@H](N)[C@H](O[C@H]9OC[C@](C)(O)[C@H](NC)[C@H]9O)[C@H]8O

InChI

1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1

InChI key

RDEIXVOBVLKYNT-HDZPSJEVSA-N

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相关类别

一般描述

化学结构：氨基糖苷类

应用

硫酸庆大霉素，是一种广谱抗生素，在分子生物学和细胞培养应用中作为选择剂（庆大霉素抗性基因）。该产品以10 mg/mL庆大霉素浓度在去离子水中配制，建议用于真核细胞培养，每升添加1毫升。

生化/生理作用

作用机制：庆大霉素可通过与核糖体的30S亚基结合来抑制蛋白质合成。

抗菌谱：包括革兰氏阴性和革兰氏阳性细菌，包括对于四环素，氯霉素，卡那霉素和粘菌素，某些特定假单胞菌菌株，变形杆菌属，Staphylococcus 和Streptococcus的抗性。

组分

庆大霉素是Micromonospora purpurea 或M. echinospora发酵后产生的氨基糖苷复合物。 它可以用来作为硫酸盐。 每摩尔庆大霉素基础有三个成分，每一个成分包含五份碱性氮，并且需要5份硫酸。

注意

该产品在37°C下可稳定5天，并在2-8°C下保存。

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H317,H334

危险分类

Resp. Sens. 1 - Skin Sens. 1

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

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Courtney R Schott et al.
PloS one, 13(10), e0206427-e0206427 (2018-10-30)
Dogs diagnosed with appendicular osteosarcoma typically succumb to metastatic disease within a year of diagnosis. The current standard of care for curative intent, amputation followed by adjuvant chemotherapy, increases survival time but chemoresistance is a major contributor to mortality. Unfortunately
Yanmin Hu et al.
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Mycobacterium tuberculosis dosRS two-component regulatory system controls transcription of approximately 50 genes including hspX, acg and Rv2030c, in response to hypoxia and nitric oxide conditions and within macrophages and mice. The hspX lies between acg and Rv2030c. However, the functions
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