所有图片(1)
About This Item
经验公式（希尔记法）:
C28H49N11O11
CAS号:
分子量:
715.76
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.32
推荐产品
生物来源
human
质量水平
方案
≥97% (HPLC)
表单
powder
技术
blocking: suitable
ligand binding assay: suitable
储存温度
−20°C
SMILES字符串
NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CN)C(O)=O
InChI
1S/C28H49N11O11/c29-8-2-1-5-16(27(49)50)37-25(47)19-7-4-10-39(19)26(48)18(14-40)38-24(46)17(11-22(43)44)36-21(42)13-34-23(45)15(35-20(41)12-30)6-3-9-33-28(31)32/h15-19,40H,1-14,29-30H2,(H,34,45)(H,35,41)(H,36,42)(H,37,47)(H,38,46)(H,43,44)(H,49,50)(H4,31,32,33)/t15-,16-,17-,18-,19-/m0/s1
InChI key
ZRVZOBGMZWVJOS-VMXHOPILSA-N
基因信息
human ... ITGA2B(3674) , ITGAV(3685)
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Amino Acid Sequence
Gly-Arg-Gly-Asp-Ser-Pro-Lys
一般描述
Gly-Arg-Gly-Asp-Ser-Pro-Lys是一种RGD肽。作为胞外基质(ECM)蛋白中的天然RGD肽，参与促进整合素介导的细胞与基质蛋白的黏附。RGD肽在细胞黏附蛋白（如纤连蛋白和玻连蛋白）中以重复形式存在。这种三肽被细胞中特定的整合素（如β1、β3和β5亚基）识别，存在于细胞表面，通过粘着斑(FA)复合物与肌动蛋白丝关联。
应用
Gly-Arg-Gly-Asp-Ser-Pro-Lys（RGD肽）已用于
- 作为抑制肽抑制整合素和纤连蛋白的结合
- 通过猪滋养外胚层粘附实验研究TGFβ（转化生长因子）对细胞粘附的影响
- 培养MC3T3-E1成骨细胞，通过AFM（原子力显微镜）检测其对细胞粘附的影响作用
- 制备RGD.Flt23k.NR纳米颗粒
- 确定RGD-整合素连接在细胞粘附过程中的参与
生化/生理作用
结合整合素的纤连蛋白类似物。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Lily Y Koo et al.
Journal of cell science, 115(Pt 7), 1423-1433 (2002-03-16)
Integrin-mediated cell adhesion is central to cell survival, differentiation and motility. Many cell responses induced by integrins require both receptor occupancy and receptor aggregation, and appear to be regulated by both biochemical and biophysical means. Multidomain extracellular matrix molecules may
Kazuyuki Onodera et al.
European journal of cell biology, 84(1), 45-58 (2005-02-24)
Biomechanical forces are major epigenetic factors that determine the form and differentiation of skeletal tissues, and may be transduced through cell adhesion to the intracellular biochemical signaling pathway. To test the hypothesis that stepwise stretching is translated to molecular signals
J Holland et al.
Biomaterials, 17(22), 2147-2156 (1996-11-01)
A synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro-Lys (GRGDSPK), which includes the cell-adhesive region of fibronectin, Arg-Gly-Asp (RGD), was covalently bound to a dialdehyde starch (DAS) coating on a polymer surface by reductive amination. The GRGDSPK/DAS-coated surface was characterized by atomic force microscopy (AFM)
Pierre-Henri Puech et al.
Journal of cell science, 118(Pt 18), 4199-4206 (2005-09-13)
During vertebrate gastrulation, progenitor cells of different germ layers acquire specific adhesive properties that contribute to germ layer formation and separation. Wnt signals have been suggested to function in this process by modulating the different levels of adhesion between the
G A Gronowicz et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 9(2), 193-201 (1994-02-01)
The role of integrins, cell surface receptors involved in cell adhesion to the matrix, was studied in a mineralizing organ culture system. Integrin-mediated cell attachment to matrix proteins has been shown to depend partially on the amino acid sequence Arg-Gly-Asp
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