所有图片(3)
About This Item
经验公式（希尔记法）:
C21H27N5O4S
CAS号:
分子量:
445.54
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
形式
solid
质量水平
颜色
white
溶解性
methanol: 1.9 mg/mL
DMSO: 48 mg/mL
SMILES字符串
Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
InChI
1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
InChI key
ZJJXGWJIGJFDTL-UHFFFAOYSA-N
基因信息
human ... ABCC8(6833) , KCNJ1(3758) , KCNJ11(3767)
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一般描述
钾内向整流通道，亚家族J，成员1（KCNJ1）可编码肾外髓质钾通道（ROMK1，Kir1.1）。 格列吡嗪是一种抗糖尿病药，可用于治疗II型糖尿病。（5）
应用
格列吡嗪已被用于：
- 雏鸡卵黄囊膜（YSM）和绒膜尿囊膜（CAM）检测
- 在绒毛膜尿囊膜（CAM）上进行的MCF-7乳腺癌检测
- 转移测定
- 大鼠主动脉环测定
- 体内基质胶塞测定
- 3-（4,5-二甲基噻唑-2-基）-2,5-二苯基溴化四氮唑（MTT）测定
- 流式细胞术
- 蛋白印迹
生化/生理作用
钾内向整流通道，亚家族J，成员1（KCNJ1）在钾平衡中起着至关重要的作用。 它是一种ATP依赖的K+通道阻断剂。其所编码的蛋白质负责消除钾，以交换钠被上皮钠通道（ENaC）吸收。 KCNJ1中的突变与多种疾病有关，例如产前Bartter综合征和糖尿病。 格列吡嗪通过预防血管生成，有助于抑制肿瘤的发展和转移。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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It remains uncertain if differences in mortality risk exist among the sulfonylureas, especially in patients with documented coronary artery disease (CAD). The purpose of this study was to assess the overall mortality risk of the individual sulfonylureas versus metformin in
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