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About This Item
经验公式（希尔记法）:
C10H12ClNO2 · HCl
CAS号:
分子量:
250.12
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32
推荐产品
表单
solid
质量水平
旋光性
[α]28/D +3.8°, c = 0.9 in methanol(lit.)
储存条件
desiccated
颜色
white
溶解性
DMSO: >20 mg/mL
H2O: 26 mg/mL (Solutions may be stored for several weeks at 4 °C.)
SMILES字符串
Cl[H].NC[C@H](CC(O)=O)c1ccc(Cl)cc1
InChI
1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1
InChI key
WMNUVYYLMCMHLU-QRPNPIFTSA-N
基因信息
human ... GABBR1(2550)
mouse ... GABBR1(54393)
rat ... GABBR1(81657)
应用
R(+)-盐酸巴氯芬已用作GABAB受体激动剂，以研究其对大鼠模型中M43068诱导的镇痛作用的影响。它还被用作GABAB受体激动剂，以研究其对鼠纹状体中安非他命诱导的行为和神经化学反应的影响。
生化/生理作用
巴氯芬是一种γ-氨基丁酸（GABA）的衍生物，可用作4-氨基丁酸受体（GABAB）激动剂。它与GABA受体立体定向相互作用并表现出抗痉挛作用。巴氯芬对三叉神经痛和脊柱痉挛的阵发性疼痛有治疗作用。R(+)-巴氯芬是一种活性更强的对映体。
其他说明
对映异构体与 R（−）-巴氯芬游离碱相同。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Xia Li et al.
Neuropharmacology, 97, 357-364 (2015-05-24)
GABAB (γ-aminobutyric acid B) receptors may be a therapeutic target for anxiety disorders. Here we characterized the effects of the GABAB receptor positive allosteric modulator (PAM) BHF177 on conditioned and unconditioned physiological responses to threat in the light-enhanced startle (LES)
Intracerebral Baclofen Administration Decreases Amphetamine-Induced Behavior and Neuropeptide Gene Expression in the Striatum
Wenxia Z, et al.
Neuropsychopharmacology, 880?890-880?890 (2004)
An efficient synthesis of (R)-and (S)-baclofen via desymmetrization
Ji L, et al.
Tetrahedron Letters, 50(45), 6166-6168 (2009)
Yuriko Watanabe et al.
European journal of pharmacology, 837, 88-95 (2018-08-08)
The nucleus accumbens contains delta-opioid receptors that may decrease inhibitory neurotransmission. As GABAB receptors inhibit dopamine release, decrease in activation of GABAB receptors may be a mediator of delta-opioid receptor-induced accumbal dopamine efflux. If so, accumbal dopamine efflux induced by
Synthesis of both enantiomers of baclofen using (R)-and (S)-N-phenylpantolactam as chiral auxiliaries
Camps P, et al.
Tetrahedron Asymmetry, 15(13) (2004)
实验方案
Qualitative Thin Layer Chromatography Analysis of Flavonoids and Quantification of Terpene Lactones in Ginkgo Biloba Extracts and Tablets
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