所有图片(3)
别名:
4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester, Plendil
经验公式（希尔记法）:
C18H19NO4Cl2
推荐产品
形式
solid
质量水平
溶解性
DMSO: 20 mg/mL
H2O: insoluble
创始人
AstraZeneca
SMILES字符串
CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(Cl)c2Cl)C(=O)OC
InChI
1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChI key
RZTAMFZIAATZDJ-UHFFFAOYSA-N
基因信息
human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779) , CACNA2D1(781) , NR3C2(4306)
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一般描述
Felodipine is a dihydropyridine derivative. It has diuretic properties. Felodipine has high vascular selectivity. It is used to treat hypertension. Felodipine regulates chronic stable angina.
生化/生理作用
L-type calcium channel blocker
特点和优势
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2 Inhalation
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Morten Schmidt et al.
European journal of clinical investigation, 42(3), 266-274 (2011-08-13)
The CYP3A4 inhibition by calcium channel blockers (CCBs) may attenuate the effectiveness of clopidogrel. Using time-varying drug exposure ascertainment, we examined whether CCB use modified the association between clopidogrel use and major adverse cardiovascular events (MACE) after coronary stent implantation.
Haiyan Li et al.
International journal of pharmaceutics, 427(2), 270-275 (2012-03-01)
Tomographic imaging techniques are attractive tools for the visualization of the internal structural characteristics of pharmaceutical solid dosage forms. In this paper, the internal structure of the tablet core for a monolith osmotic drug delivery system, felodipine sustained-release tablet, was
Ruixin Ma et al.
Journal of hypertension, 30(1), 210-216 (2011-12-03)
To evaluate the impact of felodipine with irbesartan on sexual function compared with felodipine with metoprolol in hypertensive women. This was a prospective, randomized, parallel, active-controlled, open-label study (ClinicalTrials.org: NCT01238705) in 160 women (18-60 years) with mild or moderate hypertension
Meyler's Side Effects of Cardiovascular Drugs (2009)
Sofia A Papadimitriou et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 82(1), 175-186 (2012-06-27)
In the present study, the efficiency of PVP/PEG200 mixtures as appropriate carries for the preparation of solid dispersions by melt mixing was evaluated. Felodipine (FELO) was used as a poorly water soluble model drug. The effect of several melt mixing
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