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F6777

Sigma-Aldrich

氟卡尼 乙酸盐

≥98% (TLC), powder, sodium channel blocker

别名:

N -（2-哌啶基甲基）-2,5- 双 -（2,2,2-三氟乙氧基）苯甲酰胺 乙酸盐

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5 μG
¥4,526.72
20 μG
¥11,100.17

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5 μG
¥4,526.72
20 μG
¥11,100.17

About This Item

经验公式（希尔记法）:
C17H20F6N2O3 · C2H4O2
CAS号:
54143-56-5
分子量:
474.39
EC 号:
258-997-5
MDL编号:
MFCD00214290
UNSPSC代码:
12352200
PubChem化学物质编号:
24278440
NACRES:
NA.77

¥4,526.72

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产品名称

氟卡尼 乙酸盐,

质量水平

200

创始人

Medicis

储存温度

2-8°C

SMILES字符串

CC(O)=O.FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC2CCCCN2

InChI

1S/C17H20F6N2O3.C2H4O2/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11;1-2(3)4/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26);1H3,(H,3,4)

InChI key

RKXNZRPQSOPPRN-UHFFFAOYSA-N

基因信息

human ... SCN5A(6331)

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此商品
P1787P8538P0194
Protein kinase Cα isozyme human ≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

P1782

Protein kinase Cα isozyme human

Protein Kinase CβI isozyme human ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

P1787

Protein Kinase CβI isozyme human

Protein Kinase Cδ isozyme human >95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

P8538

Protein Kinase Cδ isozyme human

Protein Kinase Cζ isozyme human ≥75% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution

P0194

Protein Kinase Cζ isozyme human

Gene Information

human ... PRKCA(5578)

Gene Information

human ... PRKCB(5579)

Gene Information

human ... PRKCD(5580)

Gene Information

human ... PRKCZ(5590)

assay

≥70% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

assay

≥75% (SDS-PAGE)

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous solution

UniProt accession no.

P17252

UniProt accession no.

P05771

UniProt accession no.

Q05655

UniProt accession no.

Q05513

生化/生理作用

IC 类抗心律失常药；钠通道阻滞药

特点和优势

该化合物在受体分类和信号转导手册的钾通道页面上有重点介绍。想要浏览手册的其他页面， 请单击此处。
该化合物由 Medicis 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表， 点击这里 。

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000419107
    0000419107
    0000317530
    0000317530
    0000264929

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    Drug therapy. Flecainide.
    D M Roden et al.
    The New England journal of medicine, 315(1), 36-41 (1986-07-03)
    P Somani
    Clinical pharmacology and therapeutics, 27(4), 464-470 (1980-04-01)
    A new class I antiarrhythmic, flecainide, was investigated in 10 patients to assess short-term efficacy and safety. All patients were hospitalized for 3 days; no antiarrhythmics were given on days 1 and 3. On day 2 flecainide 1 mg/kg was
    ThuyVy Duong et al.
    Disease models & mechanisms, 14(8) (2021-08-12)
    Clinically pertinent electrocardiogram (ECG) data from model systems, such as zebrafish, are crucial for illuminating factors contributing to human cardiac electrophysiological abnormalities and disease. Current zebrafish ECG collection strategies have not adequately addressed the consistent acquisition of high-quality traces or
    Catecholaminergic polymorphic ventricular tachycardia.
    Antoine Leenhardt et al.
    Circulation. Arrhythmia and electrophysiology, 5(5), 1044-1052 (2012-10-02)
    J C Perry et al.
    American heart journal, 124(6), 1614-1621 (1992-12-11)
    A review of all published experience with flecainide in infants, children, and fetuses was performed to evaluate the appropriate place of the drug in pediatric practice and to determine dosing guidelines. A total of 704 case references was generated. Flecainide
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