生物来源
bovine pituitary glands
质量水平
检测方案
~90% (SDS-PAGE and N-terminal analysis)
形式
lyophilized powder
效能
0.03-3.0 ng/mL ED50/EC50
质量
endotoxin tested
分子量
16.4 kDa
包装
pkg of 1 μg
储存条件
avoid repeated freeze/thaw cycles
技术
cell culture | mammalian: suitable
杂质
<0.5 EU/vial
颜色
white
UniProt登记号
储存温度
−20°C
基因信息
bovine ... FGF2(281161)
一般描述
The fibroblast growth factor-2 (FGF2) gene is predominantly expressed in uterus, cornea and vascular endothelial cells. The FGF2 gene is mapped to cattle chromosome 17.
应用
A natural mitogenic growth factor used in cell culture applications to study cell signaling and to promote fibroblast and endothelial cell growth and survival.
Fibroblast Growth Factor-Basic from bovine pituitary has been used:
Fibroblast Growth Factor-Basic from bovine pituitary has been used:
- In animal and human cell culture
- In neuronal induction of adipose and bone marrow-derived rat mesenchymal stem cells
- In the generation of directly reprogramming fibroblast
- In human glioma cell culture
生化/生理作用
Fibroblast growth factor-2 (FGF2) stimulates cell proliferation, differentiation and migration. It is also known to participate in angiogenesis and carcinogenesis. During the estrous cycle, FGF2 expression is found to be maximum in porcine conceptuses and endometrium. Upregulation of this gene is also observed in pregnancy during peri-implantation. FGF2 is involved in embryogenesis, tissue repair and other metabolic pathways.
外形
Lyophilized from a 0.2 μm filtered solution in sodium phosphate and sodium chloride containing 0.1 mg bovine serum albumin
制备说明
Purified glands by a modification of the method of Gospodarowicz, et al.
分析说明
The proliferative activity is tested in culture using fetal bovine heart endothelial cells.
相关产品
产品编号
说明
价格
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
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Stimulatory effects of fibroblast growth factor 2 on proliferation and migration of uterine luminal epithelial cells during early pregnancy
Lim W, et al.
Biology of Reproduction, 96(1), 185-198 (2016)
Kathryn A Jacobs et al.
Methods in molecular biology (Clifton, N.J.), 1749, 51-58 (2018-03-12)
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