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Merck
CN
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主要文件

安全信息

F5386

Sigma-Aldrich

纤维蛋白 来源于人类血浆

insoluble powder

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1 G
CN¥1,859.99

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1 G
CN¥1,859.99

About This Item

CAS号:
9001-31-4
EC 号:
232-597-0
MDL编号:
MFCD00131058
UNSPSC代码:
12352202
NACRES:
NA.61

CN¥1,859.99

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生物来源

human plasma

表单

powder

技术

indirect ELISA: suitable

UniProt登记号

P02671
P02675
P02679

SMILES字符串

N(CC(=O)NC)C(=O)CN

InChI

1S/C5H11N3O2/c1-7-5(10)3-8-4(9)2-6/h2-3,6H2,1H3,(H,7,10)(H,8,9)

InChI key

BWGVNKXGVNDBDI-UHFFFAOYSA-N

基因信息

human ... FGA(2243) , FGB(2244) , FGG(2266)

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F3879F6755F8630
Fibrin from human plasma insoluble powder

F5386

Fibrin from human plasma

Fibrinogen from human plasma 50-70% protein (≥80% of protein is clottable)

F3879

Fibrinogen from human plasma

Fibrinogen from rat plasma 60-80% protein (≥60% of protein is clottable)

F6755

Fibrinogen from rat plasma

Fibrinogen from bovine plasma Type I-S, 65-85% protein (≥75% of protein is clottable)

F8630

Fibrinogen from bovine plasma

biological source

human plasma

biological source

human plasma

biological source

rat plasma

biological source

bovine plasma

form

powder

form

powder

form

powder

form

powder

Gene Information

human ... FGA(2243), FGB(2244), FGG(2266)

Gene Information

human ... FGA(2243), FGB(2244), FGG(2266)

Gene Information

rat ... Fga(361969), Fgb(24366), Fgg(24367)

Gene Information

cow ... FGA(522039), FGB(510522), FGG(280792)

UniProt accession no.

P02671, P02679, P02675

UniProt accession no.

P02671, P02675, P02679

UniProt accession no.

P02680, P06399, P14480

UniProt accession no.

P02672, P02676, P12799

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

300

一般描述

纤维蛋白通过纤维蛋白原的凝血酶交联产生。纤维蛋白原由两个单体组成，每个单体含有三条多肽链。纤维蛋白原是一种主要的血浆蛋白。

应用

来自人血浆中的纤维蛋白已用于：
  • 纤维蛋白原和纤维蛋白的体外切割
  • 作为拉曼光谱真成分分析（TCA）和主成分分析（PCA）的参考
  • 作为拉曼光谱的参考，以研究不同多金属氧酸盐（POM）的结合机理和结合效率。

生化/生理作用

纤维蛋白是初级凝血过程中的重要生物聚合物。它为组织修复过程中浸润细胞提供了支架。纤维蛋白被广泛用作组织再生应用的组织密封剂，因为它能够形成生物相容性的物理结构。它也被用于细胞和生物活性分子的输送系统。纤维蛋白基质类似于天然胰腺，可作为胰岛移植的支架材料。纤维蛋白已在研究中用于获得纤维蛋白特异性单克隆抗体（mAb）。这些mAb可用于确定它们在纤维蛋白聚合中的作用以及在血浆中纤维蛋白定量中的用途。

制备说明

通过凝固纤维蛋白原制备以产生交联纤维蛋白

免责声明

供研究使用在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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    分析证书(COA)

    Lot/Batch Number
    0000418307
    0000418307
    0000398958
    0000385110
    0000339090

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    Mehmet Hamdi Kural et al.
    Experimental cell research, 319(16), 2447-2459 (2013-07-16)
    The processes of development, repair, and remodeling of virtually all tissues and organs, are dependent upon mechanical signals including external loading, cell-generated tension, and tissue stiffness. Over the past few decades, much has been learned about mechanotransduction pathways in specialized
    B J De Kort et al.
    Acta biomaterialia, 135, 243-259 (2021-09-13)
    In situ heart valve tissue engineering is an emerging approach in which resorbable, off-the-shelf available scaffolds are used to induce endogenous heart valve restoration. Such scaffolds are designed to recruit endogenous cells in vivo, which subsequently resorb polymer and produce
    Kohji Kasahara et al.
    Blood, 122(19), 3340-3348 (2013-09-05)
    Membrane rafts are spatially and functionally heterogenous in the cell membrane. We observed that lysenin-positive sphingomyelin (SM)-rich rafts are identified histochemically in the central region of adhered platelets where fibrin and myosin are colocalized on activation by thrombin. The clot
    Matthew Riopel et al.
    Acta biomaterialia, 9(9), 8140-8148 (2013-06-12)
    Extracellular matrix (ECM)-integrin stimulation can promote beta cell differentiation, proliferation and function. However, beta cells lose their insulin secretion function in response to glucose stimulation, and senesce when cultured with ECM proteins for a long time. Fibrin is a provisional
    Kristen T Morin et al.
    Experimental cell research, 319(16), 2409-2417 (2013-06-27)
    In vitro models of endothelial assembly into microvessels are useful for the study of angiogenesis and vasculogenesis. In addition, such models may be used to provide the microvasculature required to sustain engineered tissues. A large range of in vitro models
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