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Merck
CN
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文件

F3917

Sigma-Aldrich

毛喉素

For use in molecular biology applications

别名:

7β-乙酰氧基-1α,6β,9α-二羟基-8,13-环氧-半日花-14-EN-11-酮, 洋紫苏醇, 考福新

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About This Item

经验公式（希尔记法）:
C22H34O7
CAS号:
66575-29-9
分子量:
410.50
Beilstein:
1692716
EC 号:
266-410-9
MDL编号:
MFCD00082317
UNSPSC代码:
12352200
PubChem化学物质编号:
24894799
NACRES:
NA.52

生物来源

Coleus forskohlii

质量水平

200

描述

for activation of T cells

产品线

BioReagent

检测方案

≥98% (HPLC)

形式

powder

分子量

410.50  g/mol

颜色

white to off-white

溶解性

ethanol: soluble

适用性

suitable for inhibits interleukin 2 (IL-2) production in Jurkat cells

储存温度

room temp

SMILES字符串

CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C

InChI

1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1

InChI key

OHCQJHSOBUTRHG-KGGHGJDLSA-N

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一般描述

毛喉素是从Coleus forskohlii分离提取的细胞渗透双萜。

生化/生理作用

具有抗高血压、正性变力作用和腺苷酸环化酶活化特性的细胞通透性二萜类化合物。它的许多生物学作用是由于其对腺苷酸环化酶的激活以及由此而导致的细胞内cAMP浓度增加。毛喉素可影响钙电流并抑制MAP激酶。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H312

危险分类

Acute Tox. 4 Dermal

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How should I store a DMSO or ethanol solution of Product F3917, Forskolin?

    Forskolin solutions at 5 mg/mL in either ethanol or DMSO have been found to be stable for at least 6 months at room temperature, as determined by HPLC analysis.

  6. How can I make an aqueous solution of Product F3917, Forskolin?

    Forskolin is soluble in water (with 2% ethanol) up to 0.2 mM by first dissolving in ethanol at 5 mg/mL and performing subsequent dilutions in water. Similar results were obtained with DMSO.

  7. Will residual solvents inhibit forskolin activation of adenylate cyclase?

    Various solvents, including ethanol, inhibit the forskolin activation of adenylate cyclase. DMSO is recommended for preparing forskolin solutions, because at concentrations of 5% or less of DMSO, there is little if any inhibition of forskolin activation.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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实验方案

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