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Merck
CN

F3917

毛喉素

For use in molecular biology applications

别名:

7β-乙酰氧基-1α,6β,9α-二羟基-8,13-环氧-半日花-14-EN-11-酮, 洋紫苏醇, 考福新

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关于此项目

经验公式（希尔记法）:
C22H34O7
化学文摘社编号:
66575-29-9
分子量:
410.50
UNSPSC Code:
12352200
NACRES:
NA.52
PubChem Substance ID:
24894799
EC Number:
266-410-9
Beilstein/REAXYS Number:
1692716
MDL number:
MFCD00082317

主要文件

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产品名称

毛喉素, For use in molecular biology applications

InChI key

OHCQJHSOBUTRHG-KGGHGJDLSA-N

InChI

1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1

SMILES string

CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C

biological source

Coleus forskohlii

description

for activation of T cells

product line

BioReagent

assay

≥98% (HPLC)

form

powder

mol wt

410.50  g/mol

color

white to off-white

solubility

ethanol: soluble

suitability

suitable for inhibits interleukin 2 (IL-2) production in Jurkat cells

storage temp.

room temp

Quality Level

200

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Biochem/physiol Actions

具有抗高血压、正性变力作用和腺苷酸环化酶活化特性的细胞通透性二萜类化合物。它的许多生物学作用是由于其对腺苷酸环化酶的激活以及由此而导致的细胞内cAMP浓度增加。毛喉素可影响钙电流并抑制MAP激酶。

General description

毛喉素是从Coleus forskohlii分离提取的细胞渗透双萜。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H312

Hazard Classifications

Acute Tox. 4 Dermal

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000519429
0000519429
0000497468
0000497469
0000497469

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How should I store a DMSO or ethanol solution of Product F3917, Forskolin?

    Forskolin solutions at 5 mg/mL in either ethanol or DMSO have been found to be stable for at least 6 months at room temperature, as determined by HPLC analysis.

  6. How can I make an aqueous solution of Product F3917, Forskolin?

    Forskolin is soluble in water (with 2% ethanol) up to 0.2 mM by first dissolving in ethanol at 5 mg/mL and performing subsequent dilutions in water. Similar results were obtained with DMSO.

  7. Will residual solvents inhibit forskolin activation of adenylate cyclase?

    Various solvents, including ethanol, inhibit the forskolin activation of adenylate cyclase. DMSO is recommended for preparing forskolin solutions, because at concentrations of 5% or less of DMSO, there is little if any inhibition of forskolin activation.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

A Ramón-Cueto et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(10), 3803-3815 (1998-06-06)
The lack of axonal regeneration in the injured adult mammalian spinal cord leads to permanent functional impairment. To induce axonal regeneration in the transected adult rat spinal cord, we have used the axonal growth-promoting properties of adult olfactory bulb ensheathing
Jin Wei Chung et al.
Biology of reproduction, 86(3), 80-80 (2011-12-03)
The signaling molecule DHH, secreted by Sertoli cells, has essential regulatory functions in testicular differentiation. DHH is required for the differentiation of peritubular myoid cells that line the seminiferous cords and steroidogenic Leydig cells. The testicular cords in Dhh-null male
T Marchetti et al.
Journal of thrombosis and haemostasis : JTH, 12(6), 910-920 (2014-03-25)
Obstetric antiphospholipid syndrome (APS) is defined by pregnancy complications associated with antiphospholipid antibodies (aPL). The mechanisms of the pathogenic effects of aPL in pregnancy are poorly understood. Toll-like receptors (TLR) have been implicated previously in APS. The aims of our
Koji Yokoyama et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(1), 302-314 (2014-10-11)
Neonatal-onset multisystem inflammatory disease (NOMID) is a dominantly inherited autoinflammatory disease caused by NLRP3 mutations. NOMID pathophysiology is explained by the NLRP3 inflammasome, which produces interleukin-1β (IL-1β). However, epiphyseal overgrowth in NOMID is resistant to anti-IL-1 therapy and may therefore
Darren M Hutt et al.
Nature chemical biology, 6(1), 25-33 (2009-12-08)
Chemical modulation of histone deacetylase (HDAC) activity by HDAC inhibitors (HDACi) is an increasingly important approach for modifying the etiology of human disease. Loss-of-function diseases arise as a consequence of protein misfolding and degradation, which lead to system failures. The
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实验方案

Forskolin-Induced Swelling Assays using Millicell® Microwell Plates

Learn how to cultivate similar-sized iPSC-derived colon organoids using Millicell® Microwell plates and perform a forskolin-induced swelling assay.

相关内容

Data Sheet - F3917

Instructions

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