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Merck
CN
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文件

安全信息

F3261

Sigma-Aldrich

[Glu1]-纤维蛋白肽B 人

≥90% (HPLC)

别名:

Fibrinopeptide B

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About This Item

经验公式（希尔记法）:
C66H95N19O26
CAS号:
103213-49-6
分子量:
1570.57
MDL编号:
MFCD00076440
UNSPSC代码:
12352202
PubChem化学物质编号:
329799697
NACRES:
NA.32

生物来源

human

质量水平

200

检测方案

≥90% (HPLC)

形式

powder

技术

LC/MS: suitable
electrophoresis: suitable

UniProt登记号

P02675

储存温度

−20°C

SMILES字符串

CC(C)[C@H](NC(=O)CNC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C66H95N19O26/c1-31(2)53(85-48(90)29-73-55(100)35(67)16-19-49(91)92)64(109)83-42(26-46(69)88)61(106)82-43(27-52(97)98)62(107)81-41(25-45(68)87)60(105)78-37(18-21-51(95)96)57(102)77-36(17-20-50(93)94)56(101)74-28-47(89)76-39(23-33-11-6-4-7-12-33)58(103)80-40(24-34-13-8-5-9-14-34)59(104)84-44(30-86)63(108)75-32(3)54(99)79-38(65(110)111)15-10-22-72-66(70)71/h4-9,11-14,31-32,35-44,53,86H,10,15-30,67H2,1-3H3,(H2,68,87)(H2,69,88)(H,73,100)(H,74,101)(H,75,108)(H,76,89)(H,77,102)(H,78,105)(H,79,99)(H,80,103)(H,81,107)(H,82,106)(H,83,109)(H,84,104)(H,85,90)(H,91,92)(H,93,94)(H,95,96)(H,97,98)(H,110,111)(H4,70,71,72)/t32-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,53-/m0/s1

InChI key

KPBJTGOVJLITON-OECXYHNASA-N

基因信息

human ... FGB(2244)

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Amino Acid Sequence

Glu-Gly-Val-Asn-Asp-Asn-Glu-Glu-Gly-Phe-Phe-Ser-Ala-Arg

一般描述

纤维蛋白肽B （FPB）是在纤维蛋白原被凝血酶裂解为纤维蛋白单体的过程中产生的。它被从纤维蛋白原的氮端& # 946；链切割下来。这种肽由14个氨基酸组成。

应用

[Glu1]-纤维蛋白肽B人类已被用于：
  • LC-MS过程，避免交叉污染并分析质谱仪和LC仪器的性能
  • 用于2D（维）凝胶电泳期间的两点校准和通过质谱鉴定从耻垢分枝杆菌分离的组氨酸（his）-Pup（原核泛素样蛋白）的蛋白质鉴定
  • 用于一维凝胶电泳和串联质谱期间的两点校准，以表征从电气杆菌唾液腺匀浆中获得的可溶性蛋白质样品
  • 作为从胰蛋白酶消化蛋白质二硫键异构酶（PDI）获得的肽上进行的MS和MS / MS获得的数据校正质量漂移的标准

生化/生理作用

纤维蛋白的形成是伤口愈合和炎症的重要因素。纤维蛋白肽B （FPB）也能引起中性粒细胞趋化迁移，而不同时释放溶酶体酶。它是在纤维蛋白原凝固过程中产生的，纤维蛋白原对生理体内平衡至关重要。它涉及各种疾病，如血栓形成和弥散性血管内凝血。

其他说明

从0.1％TFA水溶液中冻干

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

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