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Merck
CN

F131

FPL 64176

≥98% (HPLC), powder

别名:

2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxlic acid methyl ester

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关于此项目

经验公式(希尔记法):
C22H21NO3
化学文摘社编号:
分子量:
347.41
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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InChI

1S/C22H21NO3/c1-14-19(20(15(2)23-14)22(25)26-3)21(24)18-12-8-7-11-17(18)13-16-9-5-4-6-10-16/h4-12,23H,13H2,1-3H3

SMILES string

COC(=O)c1c(C)[nH]c(C)c1C(=O)c2ccccc2Cc3ccccc3

InChI key

MDMWHKZANMNXTF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, protect from light

color

white to beige

solubility

DMSO: >20 mg/mL (Solutions should be freshly prepared.), H2O: insoluble

storage temp.

2-8°C

Quality Level

Gene Information

rat ... Cacnb3(25297)

Biochem/physiol Actions

Potent Ca2+ channel (L-type) activator.

Legal Information

Manufactured and sold with permission from Astra Charnwood.

Disclaimer

Photosensitive

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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R J Large et al.
American journal of physiology. Cell physiology, 299(5), C1180-C1194 (2010-08-20)
Hyaluronan, a joint lubricant and regulator of synovial fluid content, is secreted by fibroblast-like synoviocytes lining the joint cavity, and secretion is greatly stimulated by Ca(2+)-dependent protein kinase C. This study aimed to define synoviocyte membrane currents and channels that
Jeffrey J Ross et al.
The Journal of clinical investigation, 116(12), 3139-3149 (2006-11-14)
Smooth muscle formation and function are critical in development and postnatal life. Hence, studies aimed at better understanding SMC differentiation are of great importance. Here, we report that multipotent adult progenitor cells (MAPCs) isolated from rat, murine, porcine, and human
Valérie De Crescenzo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(29), 7565-7574 (2006-07-21)
Ca2+ stores were studied in a preparation of freshly dissociated terminals from hypothalamic magnocellular neurons. Depolarization from a holding level of -80 mV in the absence of extracellular Ca2+ elicited Ca2+ release from intraterminal stores, a ryanodine-sensitive process designated as
W Zheng et al.
Molecular pharmacology, 40(5), 734-741 (1991-11-01)
The pharmacological, radioligand binding, and electrophysiological properties of FPL 64176, a new nondihydropyridine Ca2+ channel activator, were studied in rat tail artery, cardiac membranes, and A7r5 smooth muscle cells. FPL 64176 induced a contractile response, with an EC50 value of
Louise Adermark et al.
The European journal of neuroscience, 29(1), 32-41 (2009-01-06)
Long-term depression (LTD) at striatal synapses is mediated by postsynaptic endocannabinoid (eCB) release and presynaptic cannabinoid 1 receptor (CB(1)R) activation. Previous studies have indicated that eCB mobilization at excitatory synapses might be regulated by afferent activation. To further address the

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