F131
FPL 64176
≥98% (HPLC), powder
别名:
2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxlic acid methyl ester
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关于此项目
经验公式（希尔记法）:
C22H21NO3
化学文摘社编号:
分子量:
347.41
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
protect from light
颜色
white to beige
溶解性
DMSO: >20 mg/mL (Solutions should be freshly prepared.)
H2O: insoluble
储存温度
2-8°C
SMILES字符串
COC(=O)c1c(C)[nH]c(C)c1C(=O)c2ccccc2Cc3ccccc3
InChI
1S/C22H21NO3/c1-14-19(20(15(2)23-14)22(25)26-3)21(24)18-12-8-7-11-17(18)13-16-9-5-4-6-10-16/h4-12,23H,13H2,1-3H3
InChI key
MDMWHKZANMNXTF-UHFFFAOYSA-N
基因信息
rat ... Cacnb3(25297)
相关类别
生化/生理作用
Potent Ca2+ channel (L-type) activator.
法律信息
Manufactured and sold with permission from Astra Charnwood.
免责声明
Photosensitive
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Jeffrey J Ross et al.
The Journal of clinical investigation, 116(12), 3139-3149 (2006-11-14)
Smooth muscle formation and function are critical in development and postnatal life. Hence, studies aimed at better understanding SMC differentiation are of great importance. Here, we report that multipotent adult progenitor cells (MAPCs) isolated from rat, murine, porcine, and human
Louise Adermark et al.
The European journal of neuroscience, 29(1), 32-41 (2009-01-06)
Long-term depression (LTD) at striatal synapses is mediated by postsynaptic endocannabinoid (eCB) release and presynaptic cannabinoid 1 receptor (CB(1)R) activation. Previous studies have indicated that eCB mobilization at excitatory synapses might be regulated by afferent activation. To further address the
R J Large et al.
American journal of physiology. Cell physiology, 299(5), C1180-C1194 (2010-08-20)
Hyaluronan, a joint lubricant and regulator of synovial fluid content, is secreted by fibroblast-like synoviocytes lining the joint cavity, and secretion is greatly stimulated by Ca(2+)-dependent protein kinase C. This study aimed to define synoviocyte membrane currents and channels that
W Zheng et al.
Molecular pharmacology, 40(5), 734-741 (1991-11-01)
The pharmacological, radioligand binding, and electrophysiological properties of FPL 64176, a new nondihydropyridine Ca2+ channel activator, were studied in rat tail artery, cardiac membranes, and A7r5 smooth muscle cells. FPL 64176 induced a contractile response, with an EC50 value of
Anna T Moritz et al.
Journal of neurophysiology, 98(2), 1042-1047 (2007-05-25)
Voltage-dependent persistent inward currents (PICs) make an important contribution to the input-output properties of alpha motoneurons. PICs are thought to be mediated by membrane channels located primarily on the dendrites as evidenced by prolonged tail currents following the termination of
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