质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: soluble >20 mg/mL
储存温度
room temp
SMILES字符串
[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(=O)NC(C)(C)C)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2
InChI
1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1
InChI key
DBEPLOCGEIEOCV-WSBQPABSSA-N
基因信息
human ... HSD3B1(3283) , SRD5A1(6715) , SRD5A2(6716)
rat ... Hsd3b1(360348) , Srd5a1(24950) , Srd5a2(64677)
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应用
Finasteride has been used:
- as a component of L-15 media to investigate the effects of finasteride exposure on brain, liver and testis tissues
- in culture medium to treat tumor cells in vitro
- as a positive control to treat benign prostatic hyperplasia (BPH)
- to examine its effect on structural and molecular biology on the ventral prostate of senile mice
生化/生理作用
Finasteride can reduce serum and scalp dihydrotestosterone (DHT) by preventing the transformation of testosterone to DHT. It is usually used to manage benign prostate hyperplasia and pattern hair loss in male. Finasteride possesses androgen-distracting properties.
选择性 5α-还原酶抑制剂；抗雄激素。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 1B
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
监管及禁止进口产品
Vincent Joseph et al.
Experimental physiology, 103(2), 276-290 (2017-11-24)
What is the central question of this study? What are the contributions of allopregnanolone, the neuroactive metabolite of progesterone, and nuclear (nPR) and membrane (mPR) progesterone receptors to the respiratory effect of progesterone in newborn rats? What is the main
Finasteride adverse effects: An update
Carreno-Orellana N, et al.
Revista Brasileira de Farmacognosia, 144(12), 1584-1590 (2016)
Steven T Bird et al.
The Journal of urology, 190(5), 1811-1814 (2013-05-15)
We examined the association between 5α-reductase inhibitors and male breast cancer. Study participants were men 40 to 85 years old, with prescription and medical coverage, enrolled in the United States IMS LifeLink™ Health Plan claims database between 2001 and 2009.
Douglas J Fort et al.
Journal of applied toxicology : JAT, 39(7), 1066-1078 (2019-03-09)
The impact of the perfluoro-chemical, perfluorooctanesulfonate (PFOS), on gonadal steroidogenesis during sexual differentiation in Silurana tropicalis was examined because of its ubiquity in the environment, bioaccumulative nature and potential to disturb endocrine activity. A partial life cycle study exposing S.
Finasteride in the treatment of men with androgenetic alopecia
Kaufman K D, et al.
Journal of the American Academy of Dermatology, 39(4), 578-589 (1998)
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