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Merck
CN

F1293

非那雄胺

≥98% (HPLC), Selective 5α-reductase inhibitor, powder

别名:

N-叔丁基-3-氧代-4-氮杂-5α-雄甾-1-烯-17β-甲酰胺, MK-906, N-(2-甲基-2-丙基)-3-氧代-4-氮杂-5α-雄甾-1-烯-17β-甲酰胺

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关于此项目

经验公式（希尔记法）:
C23H36N2O2
化学文摘社编号:
98319-26-7
分子量:
372.54
MDL编号:
MFCD00869737
UNSPSC代码:
41116107
PubChem化学物质编号:
24724479
NACRES:
NA.77

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产品名称

非那雄胺, ≥98% (HPLC), powder

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: soluble >20 mg/mL

储存温度

room temp

SMILES字符串

[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(=O)NC(C)(C)C)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2

InChI

1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1

InChI key

DBEPLOCGEIEOCV-WSBQPABSSA-N

基因信息

human ... HSD3B1(3283), SRD5A1(6715), SRD5A2(6716)
rat ... Hsd3b1(360348), Srd5a1(24950), Srd5a2(64677)

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相关类别

应用

Finasteride has been used:
  • as a component of L-15 media to investigate the effects of finasteride exposure on brain, liver and testis tissues
  • in culture medium to treat tumor cells in vitro
  • as a positive control to treat benign prostatic hyperplasia (BPH)
  • to examine its effect on structural and molecular biology on the ventral prostate of senile mice

生化/生理作用

选择性 5α-还原酶抑制剂；抗雄激素。
Finasteride can reduce serum and scalp dihydrotestosterone (DHT) by preventing the transformation of testosterone to DHT. It is usually used to manage benign prostate hyperplasia and pattern hair loss in male. Finasteride possesses androgen-distracting properties.

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险声明

H302,H360FD

危险分类

Acute Tox. 4 Oral - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000482204
0000482204
0000428024
0000428024
0000348493

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访问文档库

Vincent Joseph et al.
Experimental physiology, 103(2), 276-290 (2017-11-24)
What is the central question of this study? What are the contributions of allopregnanolone, the neuroactive metabolite of progesterone, and nuclear (nPR) and membrane (mPR) progesterone receptors to the respiratory effect of progesterone in newborn rats? What is the main
Finasteride adverse effects: An update
Carreno-Orellana N, et al.
Revista Brasileira de Farmacognosia, 144(12), 1584-1590 (2016)
Inhibitory effects of Ponciri Fructus on testosterone-induced benign prostatic hyperplasia in rats
Jeon W Y, et al.
BMC Complementary and Alternative Medicine, 17(1), 384-384 (2017)
Teemu J Murtola et al.
The Prostate, 73(9), 923-931 (2013-01-22)
Two clinical trials have shown that users of 5α-reductase inhibitors finasteride and dutasteride (5-ARIs) have reduced overall prostate cancer risk, while the proportion of high-grade tumors is increased. We studied tumor characteristics, risk of biochemical recurrence and mortality after radical
Mary K Samplaski et al.
Fertility and sterility, 100(6), 1542-1546 (2013-09-10)
To determine the degree of improvement in semen parameters after finasteride discontinuation. A prospective database of men presenting for a fertility evaluation was analyzed for semen and hormone parameters before and after discontinuation of finasteride. A male infertility specialty clinic.
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