F112
(+)-芬氟拉明 盐酸盐
serotonin uptake inhibitor, powder
别名:
(+)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride, Dexfenfluramine hydrochloride
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关于此项目
经验公式（希尔记法）:
C12H16F3N · HCl
化学文摘社编号:
分子量:
267.72
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
221-806-0
MDL number:
产品名称
(+)-芬氟拉明 盐酸盐,
InChI key
ZXKXJHAOUFHNAS-FVGYRXGTSA-N
InChI
1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H/t9-;/m0./s1
SMILES string
Cl[H].CCN[C@@H](C)Cc1cccc(c1)C(F)(F)F
form
powder
drug control
USDEA Schedule IV
color
white to off-white
solubility
H2O: soluble 10 mg/mL
application(s)
forensics and toxicology
storage temp.
room temp
Quality Level
Gene Information
Biochem/physiol Actions
(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic.
(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic. (+)-Fenfluramine is neurotoxic on prolonged administration or at high dosage. (+)-Fenfluramine releases serotonin from axon terminals by a nonexocytotic mechanism.
Other Notes
Active isomer
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
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L Rochette et al.
Annales de cardiologie et d'angeiologie, 57(3), 136-138 (2008-06-27)
A novel concept of "gasotransmitter" arrived recently. They are small molecules of endogenous gases. Hydrogene sulfide (H2S) is qualified as the third gasotransmitter beside nitric oxide (NO) and carbon monoxide (CO). The physiological functions of endogenous H2S are not well-known.
Rimonabant redux and strategies to improve the future outlook of CB1 receptor neutral-antagonist/inverse-agonist therapies.
Sara Jane Ward et al.
Obesity (Silver Spring, Md.), 19(7), 1325-1334 (2011-04-09)
J Scuvée-Moreau et al.
European journal of pharmacology, 179(1-2), 211-215 (1990-04-10)
The influence of acute administration of stereoisomers of fenfluramine and norfenfluramine on the firing rate of central monoaminergic neurons was investigated in rats anaesthetized with chloral hydrate. The firing rate of dorsal raphe (DR) and locus coeruleus (LC) neurons was
Effects of d- and 1-fenfluramine on striatal homovanillic acid concentrations in rats after pharmacological manipulation of brain serotonin.
V Crunelli et al.
Pharmacological research communications, 12(3), 215-223 (1980-03-01)
Delphine Natali et al.
Chest, 140(4), 1066-1068 (2011-10-06)
We report a case of pulmonary arterial hypertension (PAH) occurring in a patient with Cowden syndrome with a mutation in the phosphatase and tensin (PTEN) tumor suppressor gene, in the context of exposure to the appetite suppressant dexfenfluramine. Anorexigen exposure
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