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安全信息

F112

Sigma-Aldrich

(+)-芬氟拉明 盐酸盐

别名:

(+)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride, Dexfenfluramine hydrochloride

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About This Item

经验公式（希尔记法）:
C12H16F3N · HCl
CAS号:
3239-45-0
分子量:
267.72
EC 号:
221-806-0
MDL编号:
MFCD00069276
UNSPSC代码:
12352116
PubChem化学物质编号:
24894746
NACRES:
NA.77

表单

powder

质量水平

200

药品控制

USDEA Schedule IV

颜色

white to off-white

溶解性

H2O: soluble 10 mg/mL

应用

forensics and toxicology

储存温度

room temp

SMILES字符串

Cl[H].CCN[C@@H](C)Cc1cccc(c1)C(F)(F)F

InChI

1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H/t9-;/m0./s1

InChI key

ZXKXJHAOUFHNAS-FVGYRXGTSA-N

基因信息

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR6(3362) , HTR7(3363)

生化/生理作用

(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic.
(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic. (+)-Fenfluramine is neurotoxic on prolonged administration or at high dosage. (+)-Fenfluramine releases serotonin from axon terminals by a nonexocytotic mechanism.

其他说明

Active isomer

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301 + H311 + H331

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000333406
0000333406
SLBJ7261V
SLBF9148V
075K4714

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L Rochette et al.
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A novel concept of "gasotransmitter" arrived recently. They are small molecules of endogenous gases. Hydrogene sulfide (H2S) is qualified as the third gasotransmitter beside nitric oxide (NO) and carbon monoxide (CO). The physiological functions of endogenous H2S are not well-known.
Rimonabant redux and strategies to improve the future outlook of CB1 receptor neutral-antagonist/inverse-agonist therapies.
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Obesity (Silver Spring, Md.), 19(7), 1325-1334 (2011-04-09)
Rex W Watkins et al.
Chemical communications (Cambridge, England), 47(3), 973-975 (2010-11-17)
The S-peptide and S-protein components of bovine pancreatic ribonuclease form a noncovalent complex with restored ribonucleolytic activity. Although this archetypal protein-fragment complementation system has been the object of historic work in protein chemistry, intrinsic limitations compromise its utility. Modern methods
Sanjeev Bhattacharyya et al.
Lancet (London, England), 374(9689), 577-585 (2009-08-18)
The initial association between the development of valvular heart disease and drugs stems from observations made during the use of methysergide and ergotamine for migraine prophylaxis in the 1960s. Since then, the appetite suppressants fenfluramine and dexfenfluramine, the dopamine agonists
[Image of the month. A case of aortic regurgitation association with dexfenfluramine].
L Bouffioux et al.
Revue medicale de Liege, 64(9), 432-433 (2009-12-02)
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