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检测方案
≥98% (HPLC)
形式
solid
颜色
white
溶解性
DMSO: ≥20 mg/mL
H2O: insoluble
ethanol: soluble
创始人
Johnson & Johnson
储存温度
room temp
SMILES字符串
Fc1ccc(cc1)C(CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4)c5ccc(F)cc5
InChI
1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)
InChI key
QOYHHIBFXOOADH-UHFFFAOYSA-N
基因信息
human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)
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应用
氟司必林已用于研究其作为神经安定药物对人ether-a-go-go相关基因(HERG)的影响。
氟司必林已用于研究其对恶性神经胶质瘤的细胞毒性作用。
生化/生理作用
氟司必林(Fluspirilene)是一种多巴胺受体拮抗剂。也可充当钙通道阻断剂。氟司必林是一种抗精神病药物，具有精神安定作用。对胶质母细胞瘤和精神分裂症有治疗作用。
氟司必林可抑制周期蛋白依赖性激酶2(CDK2)的活性。可作为抗癌药有效治疗人肝细胞癌。
特点和优势
该化合物由 Johnson & Johnson 开发。浏览其他由制药公司开发的化合物以及批准药物/候选药物清单， 请单击此处。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Inhibition of P-type and N-type calcium channels by dopamine receptor antagonists.
Sah, DW and Bean, Bruce P
Molecular Pharmacology, 45(1), 84-92 (1994)
Qin Cao et al.
Nature chemistry (2018-10-10)
Inhibiting the interaction between amyloid-β (Aβ) and a neuronal cell surface receptor, LilrB2, has been suggested as a potential route for treating Alzheimer's disease. Supporting this approach, Alzheimer's-like symptoms are reduced in mouse models following genetic depletion of the LilrB2
Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug
Dong Y, et al.
Oncotarget, 8(67), 111728-111728 (2017)
In silico identification and in vitro and in vivo validation of anti-psychotic drug fluspirilene as a potential CDK2 inhibitor and a candidate anti-cancer drug
Shi XN, et al.
PLoS ONE, 10(7), e1753-e1753 (2015)
D W Sah et al.
Molecular pharmacology, 45(1), 84-92 (1994-01-01)
P-type Ca2+ channels in cerebellar Purkinje neurons and N-type Ca2+ channels in sympathetic neurons were found to be inhibited by D2 dopamine receptor antagonists with diverse structures, including phenothiazines (chlorpromazine and thioridazine), diphenylbutylpiperidines (fluspirilene and pimozide), butyrophenones (haloperidol and spiperone)
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