描述
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质量水平
产品线
MISSION®
表单
lyophilized powder
esiRNA cDNA靶序列
TTTCACAGCCAACGACTCTGGCCATCGCCACTACACCATCGCAGCCCTGCTCAGCCCATACTCCTACAGCACCACGGCTGTCGTCAGCAACCCCCAGAATTGAGAGACTCAGCCCAGGAGGACCAGGATCTTGCCAAAGCAGTAGCATCCCATTTGTACCAAAACAGTGTTCTTGCTCTATAAACCGTGTTAGCAGCTCAGGAAGATGCCGTGAAGCATTCTTATTAAACCACCTGCTATTTCATTCAAACTGTGTTTCTTTTTTATTTCCTCATTTTTCTCCCCTGCTCCTAAAACCCAAAATTTTTTAAAGAATTCTAGAAGGTATGCGATCAAACTTTTTAAAGAAAGAAAATACTTTTTGACTCATGGTTTAAAGGCATCCTTTCCATCTTGGGGAGGTCATGGGTGCTCCTGGCAACTTGCTTGAGGAAGATAGGTCAGAAAGCAGAGTGGACCAACCGTTCAAT
基因组数据库 |小鼠登记号
NCBI登记号
运输
ambient
储存温度
−20°C
基因信息
mouse ... TTR(22139) , Ttr(22139)
一般描述
MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.
For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.
For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.
法律信息
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Nádia P Gonçalves et al.
Acta neuropathologica communications, 2, 177-177 (2014-12-19)
Transthyretin V30M mutation is the most common variant leading to Familial Amyloidotic Polyneuropathy. In this genetic disorder, Transthyretin accumulates preferentially in the extracellular matrix of peripheral and autonomic nervous systems leading to cell death and dysfunction. Thus, knowledge regarding important
Ole B Suhr et al.
Orphanet journal of rare diseases, 10, 109-109 (2015-09-05)
Transthyretin-mediated amyloidosis is an inherited, progressively debilitating disease caused by mutations in the transthyretin gene. This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple doses of patisiran (ALN-TTR02), a small interfering RNA encapsulated within lipid nanoparticles, in patients
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