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EHU134591

MISSION^® esiRNA

Name: MISSION<SUP>®</SUP> esiRNA
Brand: SIGMA
Price: 5330.94 CNY
Availability: InStock

targeting human PDE4B

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100 μL

¥5,330.94

200 μL

¥7,286.29

¥5,330.94

目录价¥6,023.96节省 12%

国内现货，预计发货时间2025年4月10日详情

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100 μL

¥5,330.94

200 μL

¥7,286.29

About This Item

UNSPSC代码:

41105324

NACRES:

NA.51

¥5,330.94

目录价¥6,023.96节省 12%

国内现货，预计发货时间2025年4月10日详情

描述

产品线

MISSION^®

表单

lyophilized powder

esiRNA cDNA靶序列

TCCAGGAAAGAGACCTCCTAAAGACATTCAGAATCTCATCTGACACATTTATAACCTACATGATGACTTTAGAAGACCATTACCATTCTGACGTGGCATATCACAACAGCCTGCACGCTGCTGATGTAGCCCAGTCGACCCATGTTCTCCTTTCTACACCAGCATTAGACGCTGTCTTCACAGATTTGGAGATCCTGGCTGCCATTTTTGCAGCTGCCATCCATGACGTTGATCATCCTGGAGTCTCCAATCAGTTTCTCATCAACACAAATTCAGAACTTGCTTTGATGTATAATGATGAATCTGTGTTGGAAAATCATCACCTTGCTGTGGGTTTCAAACTGCTGCAAGAAGAACACTGTGACATCTTCATGAATCTCACCAAGAAGCAGCGTCAGACAC

基因组数据库 |人类登记号

ENSG00000184588

NCBI登记号

NM_001037339

运输

ambient

储存温度

−20°C

基因信息

human ... PDE4B(5142) , PDE4B(5142)

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此商品	P0834	81007N	81070N
P0914 蛋白标准品	P0834 蛋白标准品	81007N Probumin^® Bovine Serum Albumin Microbiological Grade, 30% Solution	81070N Probumin^® Bovine Serum Albumin Manufacturing Grade, 30% Solution
technique(s) ELISA: suitable	technique(s) ELISA: suitable	technique(s) cell culture \| mammalian: suitable, enzyme immunoassay: suitable, microbiological culture: suitable, western blot: suitable	technique(s) blood typing: suitable, enzyme immunoassay: suitable
Quality Level 200	Quality Level 200	Quality Level 300	Quality Level 300
form liquid	form liquid	form solution	form solution
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
packaging ampule of 1 mL	packaging -	packaging pack of 50 mL	packaging pack of 50 mL

一般描述

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

法律信息

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

技术规格说明书

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

XZS

QLS

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Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) sponges microRNA-124-3p to up-regulate phosphodiesterase 4B (PDE4B) to accelerate the progression of Parkinson's disease.

Ming-Yu Chen et al.

Bioengineered, 12(1), 708-719 (2021-02-02)

Reportedly, long non-coding RNA (lncRNA) are crucial modulators in neurodegenerative diseases. Herein, we investigated the role of lncRNA nuclear enriched abundant transcript 1 (NEAT1) in Parkinson's disease (PD). In-vitro PD model was established based on SH-SY5Y cells treated with 1-methyl-4-phenylpyridinium

Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy.

Xue-Qi Liu et al.

Biochemical pharmacology, 180, 114132-114132 (2020-07-06)

Acute kidney injury (AKI), characterized by a rapid decline in renal function, is triggered by an acute inflammatory response that leads to kidney damage. An effective treatment for AKI is lacking. Using in vitro and in vivo AKI models, our

Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/Sirt1 pathway.

Dan Li et al.

International immunopharmacology, 90, 107176-107176 (2020-11-28)

Roflupram (ROF) is a novel phosphodiesterase 4 inhibitor. We previously found that ROF suppressed the production of pro-inflammatory factors in microglial cells; however, the underlying mechanisms are largely unknown. The present study aimed to elucidate the underlying molecular mechanisms of

Inhibition of PDE4 Attenuates TNF-α-Triggered Cell Death Through Suppressing NF-κB and JNK Activation in HT-22 Neuronal Cells.

Jiao Xiao et al.

Cellular and molecular neurobiology, 40(3), 421-435 (2019-10-30)

Tumor necrosis factor-α (TNF-α) is a critical pro-inflammatory cytokine regulating neuroinflammation. At high concentrations, it is toxic to neurons, and such damage is positively correlated with acute and chronic neurological diseases. Our previous studies showed that inhibition of phosphodiesterase 4

Inhibition of PDE4 by FCPR16 induces AMPK-dependent autophagy and confers neuroprotection in SH-SY5Y cells and neurons exposed to MPP+-induced oxidative insult.

Jiahong Zhong et al.

Free radical biology & medicine, 135, 87-101 (2019-03-01)

The etiology of Parkinson's disease (PD) is generally not well understood, but it is believed to involve excessive oxidative insult. Hence, identifying therapeutic targets and compounds that exhibit protective effects against oxidative damage is a reasonable strategy to slow down

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MISSION^® esiRNA

targeting human PDE4B

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