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Merck
CN

ED4SS

Sigma-Aldrich

乙二胺四乙酸 四钠盐 二水合物

99.0-102.0% (titration)

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别名:
EDTA 四钠盐, 乙二胺四乙酸四钠盐 二水合物, 依地酸钙钠
线性分子式:
(NaOOCCH2)2NCH2CH2N(CH2COONa)2 · 2H2O
CAS号:
分子量:
416.20
Beilstein:
3861753
EC 号:
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

99.0-102.0% (titration)

形式

crystalline

反应适用性

reagent type: chelator

溶解性

H2O: soluble, clear, colorless

SMILES字符串

O.O.[Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.4Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;;;2*1H2/q;4*+1;;/p-4

InChI key

KSYNLCYTMRMCGG-UHFFFAOYSA-J

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一般描述

乙二胺四乙酸(EDTA)是一种多元酸,用作金属螯合剂。由4个羧基和2个氨基组成,孤对电子可螯合钙等多种金属离子。 

应用

乙二胺四乙酸四钠盐二水合物已用于:
  • 使股骨脱钙,用于骨软骨组织的组织处理和染色
  • 作为NH4Cl裂解缓冲液组分,用于红细胞裂解和整体鉴定
  • 分离小鼠结缔组织隐窝

生化/生理作用

乙二胺四乙酸(EDTA)可治疗重金属离子中毒患者。EDTA可抑制金属蛋白酶活性位点的锌离子,也可抑制其他金属离子依赖性蛋白酶,如钙依赖性半胱氨酸蛋白酶。EDTA可能会干扰金属依赖性生物学过程。EDTA可抑制血小板聚集,并且是血小板计数最常用的抗凝剂。EDTA可联合其他活性试剂抑制微生物和生物膜,例如柠檬酸、醇、抗生素、聚六亚甲基双胍(PHMB)季铵等消毒剂。EDTA可用作血液学检验的抗凝剂,稳定血细胞的细胞组分和形态。 
乙二胺四乙酸(EDTA)用于消除痕量重金属对酶的抑制作用,并抑制需要二价阳离子作为辅因子的酶。

警示用语:

Danger

危险分类

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2

靶器官

Respiratory Tract

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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商品

Cathepsin B is a lysosomal cysteine proteinase with broad specificity. This protocol uses Nα–CBZ–Arg–Arg–7–amido–4–methylcoumarin as the substrate for fluorometric detection of Cathepsin B activity.

组织蛋白酶B是具有广泛特异性的溶酶体半胱氨酸蛋白酶。本方案采用Nα–CBZ–Arg–Arg–7–酰胺基-4-甲基香豆素作为荧光检测组织蛋白酶B活性的底物。

实验方案

Objective: To standardize a procedure for the recycling micro-assay of β-NAD and β-NADH

Enzymatic Assay of α-Glucosidase by the Modified Boehenger Procedure (EC 3.2.1.20)

在进行β-NAD和β-NADH的回收微量分析时,使用了在570 nm处的连续分光光度法进行测定。

改良Boehenger法酶促检测α-葡萄糖苷酶(EC 3.2.1.20)

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