E7881
大黄素
from Frangula bark, ≥90% (HPLC), casein Kinase 2 (CK2) inhibitor
别名:
1,3,8-三羟基-6-甲基-9,10-蒽醌, 1,3,8-三羟基-6-甲基蒽醌, 6-甲基-1,3,8-三羟基蒽醌, 大黃甘, 朱砂莲甲素, 泻素, 泻鼠李树皮, 虎杖大黄素
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关于此项目
经验公式（希尔记法）:
C15H10O5
化学文摘社编号:
分子量:
270.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
208-258-8
MDL number:
Beilstein/REAXYS Number:
1888141
Assay:
≥90% (HPLC)
Quality level:
产品名称
大黄素, from Frangula bark, ≥90% (HPLC)
InChI
1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
InChI key
RHMXXJGYXNZAPX-UHFFFAOYSA-N
SMILES string
Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
biological source
Frangula bark
assay
≥90% (HPLC)
solubility
DMSO: soluble
aqueous base: soluble
ethanol: soluble
storage temp.
2-8°C
Quality Level
Gene Information
human ... CSNK2A1(1457), CSNK2B(1460), ELA2(1991), NFKB1(4790), NKAP(79576), NKRF(55922)
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Application
大黄素已被用于：
- 研究其对脂多糖 (LPS) 诱导的心肌炎炎症损伤的调控机制
- 作为开发和验证高效液相色谱 (HPLC)-光电二极管阵列 (PDA) 检测的参考标准品
- 抑制 Tau 聚集
- 用于直接结合检测
Biochem/physiol Actions
抑制 NF-κB 活化和粘附分子表达。酪蛋白激酶 2 (CK2) 抑制剂。
General description
大黄素是一种从大黄 (Rheum palmatum) 中提取出来的蒽醌衍生物。 它具有抗菌、 抗肿瘤、抗炎和抗血管生成等作用。大黄素具有细胞毒性作用、诱导细胞凋亡并刺激缺氧诱导因子1α、谷胱甘肽 S-转移酶P和 N-乙酰转移酶的表达。 它可以抑制前列腺癌细胞的生长。 大黄素被用于治疗便秘和痔疮。它显示出免疫抑制和抗糖尿病作用。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Sheng-Zhang Lin et al.
PloS one, 7(8), e42146-e42146 (2012-08-10)
Emodin has been showed to induce apoptosis of pancreatic cancer cells and inhibit tumor growth in our previous studies. This study was designed to investigate whether emodin could inhibit the angiogenesis of pancreatic cancer tissues and its mechanism. In accordance
Casein kinase 2 (CK2)-mediated phosphorylation of Hsp90beta as a novel mechanism of rifampin-induced MDR1 expression
Kim SW, et al.
The Journal of Biological Chemistry, 290(27), 17029-17040 (2015)
Anticancer potential of emodin
Hsu SC and Chung JG
BioMedicine, 2(3), 108-116 (2012)
Hajer Ouertatani-Sakouhi et al.
The Journal of biological chemistry, 285(34), 26581-26598 (2010-06-03)
Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, is considered an attractive therapeutic target in multiple inflammatory and autoimmune disorders. In addition to its known biologic activities, MIF can also function as a tautomerase. Several small molecules have been reported
Emodin and aloe-emodin suppress breast cancer cell proliferation through ERalpha inhibition
Huang PH, et al.
Evidence-Based Complementary and Alternative Medicine : ECAM, 2013 (2013)
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