所有图片(1)
别名:
2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol
经验公式（希尔记法）:
C18H18N4O2S
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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
yellow
溶解性
DMSO: >20 mg/mL
储存温度
2-8°C
SMILES字符串
COc1cc(ccc1O)\C=N\Nc2ncnc3sc4CCCCc4c23
InChI
1S/C18H18N4O2S/c1-24-14-8-11(6-7-13(14)23)9-21-22-17-16-12-4-2-3-5-15(12)25-18(16)20-10-19-17/h6-10,23H,2-5H2,1H3,(H,19,20,22)/b21-9+
InChI key
VFNUTEMVQGLDAG-ZVBGSRNCSA-N
生化/生理作用
Exo2 acts as a chemical probe of intracellular transport. Edxo2 has activities similar to Brefeldin A with membrane trafficking to the Golgi appartus, but appears more selective.
Exo2 is a bioactive small molecule that activates Golgi-endoplasmic reticulum (ER) fusion in mammals by distorting the Golgi apparatus. It prevents the release of secretory cargo from the ER. Exo2 do not modify the morphology of the trans-Golgi network (TGN). It also inhibits the anterograde movement of vesicular stomatitis virus G (VSV G) glycoprotein, from ER to Golgi.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Lexiang Ji et al.
The Plant cell, 31(10), 2315-2331 (2019-08-24)
Somatic embryogenesis is an important tissue culture technique that sometimes leads to phenotypic variation via genetic and/or epigenetic changes. To understand the genomic and epigenomic impacts of somatic embryogenesis, we characterized soybean (Glycine max) epigenomes sampled from embryos at 10
Combined targeting of Arf1 and Ras potentiates anticancer activity for prostate cancer therapeutics.
Liwei Lang et al.
Journal of experimental & clinical cancer research : CR, 36(1), 112-112 (2017-08-24)
Although major improvements have been made in surgical management, chemotherapeutic, and radiotherapeutic of prostate cancer, many prostate cancers remain refractory to treatment with standard agents. Therefore, the identification of new molecular targets in cancer progression and development of novel therapeutic
Gertrud Wiedemann et al.
The Plant cell, 30(3), 717-736 (2018-03-09)
RecQ DNA helicases are genome surveillance proteins found in all kingdoms of life. They are characterized best in humans, as mutations in RecQ genes lead to developmental abnormalities and diseases. To better understand RecQ functions in plants we concentrated on
Robert A Spooner et al.
The Biochemical journal, 414(3), 471-484 (2008-06-05)
The small-molecule inhibitor Exo2 {4-hydroxy-3-methoxy-(5,6,7,8-tetrahydrol[1]benzothieno[2,3-d]pyrimidin-4-yl)hydraz-one benzaldehyde} has been reported to disrupt the Golgi apparatus completely and to stimulate Golgi-ER (endoplasmic reticulum) fusion in mammalian cells, akin to the well-characterized fungal toxin BFA (brefeldin A). It has also been reported that
Ayaka Hieno et al.
Plant physiology, 180(3), 1629-1646 (2019-05-09)
Hydrogen peroxide (H2O2) is a common signal molecule initiating transcriptional responses to all the known biotic and abiotic stresses of land plants. However, the degree of involvement of H2O2 in these stress responses has not yet been well studied. Here
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