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Merck
CN

E7138

乙琥胺

T-type calcium channel antagonist

别名:

2-乙基-2-甲基琥珀酰亚胺

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关于此项目

经验公式(希尔记法):
C7H11NO2
化学文摘社编号:
分子量:
141.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352111
EC Number:
201-048-7
MDL number:
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产品名称

乙琥胺,

InChI

1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)

InChI key

HAPOVYFOVVWLRS-UHFFFAOYSA-N

SMILES string

O=C1NC(CC1(C)CC)=O

solubility

ethanol: 100 mg/mL

Quality Level

Gene Information

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Application

乙琥胺已被用于:
  • 证实其对大鼠棘波放电(SWD)的作用
  • 考察其对野生型斑马鱼幼体自发运动和焦虑相关趋触性行为的影响
  • 作为模型药物体内治疗癫痫症(4)

Biochem/physiol Actions

乙琥胺是一种抗惊厥药,同时也是T型钙通道拮抗剂。它可防止失神发作中的棘波放电。

Features and Benefits

该化合物在受体分类和信号转导手册的钙通道页面上有重点介绍。如需浏览其他手册页面,请点击此处

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Behavioural responses of zebrafish larvae to acute ethosuximide exposure
Ji Y, et al.
Behavioural Pharmacology, 28(6), 428-440 (2017)
N Leresche et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(13), 4842-4853 (1998-06-23)
The action of ethosuximide (ETX) on Na+, K+, and Ca2+ currents and on tonic and burst-firing patterns was investigated in rat and cat thalamic neurons in vitro by using patch and sharp microelectrode recordings. In thalamocortical (TC) neurons of the
Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy
Pearce PS, et al.
Epilepsy & Behavior : E&B, 32, 121-131 (2014)
Shang-Der Chen et al.
Epilepsia, 52(7), 1311-1318 (2011-07-07)
Generalized absence seizures are characterized by bilateral spike-wave discharges (SWDs), particularly in the frontoparietal cortical region. In WAG/Rij and GAERS rats with absence epilepsy, recent evidence indicates that SWDs arise first from the lateral somatosensory cortex (LSC), that is, the

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