E7138
乙琥胺
T-type calcium channel antagonist
别名:
2-乙基-2-甲基琥珀酰亚胺
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关于此项目
经验公式（希尔记法）:
C7H11NO2
化学文摘社编号:
分子量:
141.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352111
EC Number:
201-048-7
MDL number:
产品名称
乙琥胺,
InChI
1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
InChI key
HAPOVYFOVVWLRS-UHFFFAOYSA-N
SMILES string
O=C1NC(CC1(C)CC)=O
solubility
ethanol: 100 mg/mL
Quality Level
Gene Information
human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)
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相关类别
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Journal of Materials Chemistry, 22(17), 8566-8573 (2012)
Behavioural responses of zebrafish larvae to acute ethosuximide exposure
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Behavioural Pharmacology, 28(6), 428-440 (2017)
N Leresche et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(13), 4842-4853 (1998-06-23)
The action of ethosuximide (ETX) on Na+, K+, and Ca2+ currents and on tonic and burst-firing patterns was investigated in rat and cat thalamic neurons in vitro by using patch and sharp microelectrode recordings. In thalamocortical (TC) neurons of the
Emilio Russo et al.
Epilepsia, 52(7), 1341-1350 (2011-06-04)
Depression is most commonly associated with epilepsy. Recent reports have suggested a putative relationship between seizure development and onset of depressive behavior, whereas others proposed that two clinical entities might represent different neuropathologic aspects of the same neurologic disorder. The
Gilles van Luijtelaar et al.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 85(1), 49-54 (2011-09-29)
Recently it was established that early long lasting treatment with the anti-absence drug ethosuximide (ETX) delays the occurrence of absences and reduces depressive-like symptoms in a genetic model for absence epilepsy, rats of the WAG/Rij strain. Here it is investigated
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