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Merck
CN
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安全信息

E6657

Sigma-Aldrich

Eplerenone

≥98% (HPLC)

别名:

9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester, Cgp 30083, Eplerenone [USAN], Epoxymexrenone, HSDB 7522, Inspra, Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-, SC-66110

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About This Item

经验公式（希尔记法）:
C24H30O6
CAS号:
107724-20-9
分子量:
414.49
MDL编号:
MFCD05662207
UNSPSC代码:
51111800
PubChem化学物质编号:
329798999
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear (warmed)
H2O: insoluble

储存温度

2-8°C

SMILES字符串

O1[C@]32[C@H]1C[C@@]4([C@@]6(OC(=O)CC6)CC[C@H]4[C@@H]3[C@@H](CC5=CC(=O)CC[C@@]52C)C(=O)OC)C

InChI

1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

InChI key

JUKPWJGBANNWMW-VWBFHTRKSA-N

基因信息

human ... NR3C2(4306)

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一般描述

Eplerenone is an aldosterone blocker, which particularly blocks mineralocorticoid receptor. It reduces cardiovascular risk in patients following acute myocardial infarction. Eplerenone is used for treating hypertension and central serous retinopathy. It exhibits potassium sparing diuretic effect.

应用

Eplerenone has been used in quantitative real time (RT-qPCR) or western blotting assays.

生化/生理作用

Eplerenone is an aldosterone antagonist more specific for the mineralocorticoid receptor than spironolactone (S3378), having lower affinity for progesterone, androgen, and glucocorticoid receptors.
Eplerenone is an aldosterone antagonist.

特点和优势

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000371039
0000321811
0000371039
0000321811
0000229235

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C Mondadori et al.
Psychopharmacology, 124(4), 380-383 (1996-04-01)
The retention performance of mice in a passive-avoidance task was facilitated by low doses (0.3 mg/kg) of the competitive NMDA-receptor blocker CGP 37849, but impaired by high doses (30 mg/kg). The facilitatory effect was selectively suppressed by elevation of the
Tracy Ann Williams et al.
The Journal of clinical endocrinology and metabolism, 100(9), E1262-E1269 (2015-07-16)
Coexisting prolactinoma-primary aldosteronism (PA) is infrequently reported. The objective of the study was to identify patients with prolactinoma-PA and test the hypothesis that elevated prolactin (PRL) concentrations play a role in PA pathogenesis. Hyperprolactinemia/prolactinoma was diagnosed in PA patients from
Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension
Weinberger MH, et al.
American Journal of Hypertension, 15(8), 709-716 (2002)
Oral eplerenone for treatment of chronic central serous chorioretinopathy: a case series
Sal DA, et al.
Ophthalmic Surgery, Lasers & Imaging Retina, 46(4), 439-444 (2015)
M de Gasparo et al.
Journal of steroid biochemistry, 32(1B), 223-227 (1989-01-01)
The use of spironolactone in the treatment of hypertension has been limited by the occurrence of sexual side effects, mainly menstrual disturbances in women and gynaecomastia in men. In order to minimize this limitation on the use of an effective
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