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E5406

Sigma-Aldrich

爱普杷嗪 盐酸盐

≥98% (HPLC), powder

别名:

10-(2-二乙氨基丙基)吩噻嗪, 10-[2-(二乙氨基)丙基]吩噻嗪 盐酸盐, 乙丙嗪, 二乙异丙嗪 盐酸盐

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About This Item

经验公式（希尔记法）:
C19H24N2S · HCl
CAS号:
1094-08-2
分子量:
348.93
EC 号:
214-134-4
MDL编号:
MFCD00012653
UNSPSC代码:
12352200
PubChem化学物质编号:
329799070
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white

溶解性

DMSO: >5 mg/mL at ~60 °C, clear

储存温度

2-8°C

SMILES字符串

Cl[H].CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13

InChI

1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H

InChI key

VXPCQISYVPFYRK-UHFFFAOYSA-N

基因信息

human ... CHRM1(1128)

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一般描述

盐酸乙氧丙嗪具有抗胆碱能、抗组胺和抗肾上腺素能特性。

生化/生理作用

爱普杷嗪盐酸盐是一种丁酰胆碱酯酶的抑制剂；抗帕金森症药物
爱普杷嗪盐酸盐是一种丁酰胆碱酯酶的抑制剂；抗帕金森症药物。它可以减轻帕金森症的典型症状，即锥体外系副反应；还可以减轻小鼠的热痛觉过敏症状。

特点和优势

该化合物收录于受体分类和信号转导手册的《乙酰胆碱合成与代谢》页面。想要浏览手册的其他页面， 请单击此处。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000235829
0000235829
0000134513
0000129675
0000129676

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Transition Metal Complexes of Ethopropazine: Synthesis and Characterization
Debbeti V, et al.
American Journal of Chemistry, 2(6), 294-298 (2012)
Katherine C M Chew et al.
PloS one, 6(5), e19720-e19720 (2011-06-01)
Mutations in the parkin gene, which encodes a ubiquitin ligase (E3), are a major cause of autosomal recessive parkinsonism. Although parkin-mediated ubiquitination was initially linked to protein degradation, accumulating evidence suggests that the enzyme is capable of catalyzing multiple forms
Derek P Narendra et al.
PLoS biology, 8(1), e1000298-e1000298 (2010-02-04)
Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy. How Parkin recognizes damaged mitochondria, however, is unknown. Here, we
Nickie C Chan et al.
Human molecular genetics, 20(9), 1726-1737 (2011-02-08)
Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin-proteasome system (UPS) for widespread degradation of outer membrane
Joe H Pogson et al.
PLoS genetics, 10(11), e1004815-e1004815 (2014-11-21)
Mutations in PINK1, a mitochondrially targeted serine/threonine kinase, cause autosomal recessive Parkinson's disease (PD). Substantial evidence indicates that PINK1 acts with another PD gene, parkin, to regulate mitochondrial morphology and mitophagy. However, loss of PINK1 also causes complex I (CI)
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