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生物来源
synthetic
无菌性
non-sterile
方案
≥98%
表单
powder
mp
182-183 °C (lit.)
溶解性
ethanol: 50 mg/mL, clear, colorless to faintly yellow
运输
ambient
储存温度
room temp
SMILES字符串
[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])CCc4cc(O)ccc24
InChI
1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1
InChI key
BFPYWIDHMRZLRN-SLHNCBLASA-N
基因信息
human ... ESR1(2099)
rat ... Afp(24177) , Esr1(24890) , Shbg(24775)
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一般描述
17α-乙炔雌二醇 (EE2) 是一种人工合成的激素，为雌二醇 (E2) 的衍生物。与雌激素替代治疗和暂停哺乳有关。EE2 用于治疗骨质疏松症、更年期和绝经后综合症。也用于治疗绝经后妇女的前列腺癌和乳腺癌。EE2 作为内分泌干扰物 (EDC) 发挥作用。
应用
17α-乙炔雌二醇已被用于研究外源性雌激素和选择性雌激素受体调节剂 (SERM) 在大鼠中的作用。它还被用于增加兔肝脏中低密度脂蛋白 (LDL) 受体的浓度。
生化/生理作用
17α-炔雌醇是一种口服生物活性合成雌激素，用作口服避孕药。
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 2 - Repr. 1A
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
涉药品监管产品
Analysis of 17-beta-estradiol and 17-alpha-ethinylestradiol in biological and environmental matrices?a review
Barreiros L, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 126, 243-262 (2016)
Purification of low density lipoprotein receptor from liver and its quantification by anti-receptor monoclonal antibodies
Gherardi E, et al.
The Biochemical Journal, 253(2), 409-415 (1988)
Huda Omar Ali et al.
PloS one, 11(3), e0152114-e0152114 (2016-03-22)
Oestrogens influence the pathology and development of hormone-sensitive breast cancers. Tissue factor pathway inhibitor (TFPI) has been shown to be associated with breast cancer pathogenesis. Recently, we found TFPI mRNA levels to be significantly reduced by oestrogens in a breast
Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application
Hoegh-Andersen P, et al.
Arthritis Research & Therapy, 6(2), R169-R169 (2004)
Occurrence of 17alpha-ethynylestradiol (EE2) in the environment and effect on exposed biota: a review
Aris AZ, et al.
Environment International, 69, 104-119 (2014)
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