质量水平
检测方案
≥98% (HPLC)
形式
powder
旋光性
[α]27/D −7.2°, c = 0.3 in methanol(lit.)
储存条件
desiccated
颜色
off-white
溶解性
H2O: soluble >10 mg/mL
ethanol: soluble 2.6 mg/mL
0.1 M HCl: soluble 7 mg/mL
SMILES字符串
Cl.CCN1CCC[C@H]1CNC(=O)c2c(O)c(CC)cc(Cl)c2OC
InChI
1S/C17H25ClN2O3.ClH/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2;/h9,12,21H,4-8,10H2,1-3H3,(H,19,22);1H/t12-;/m0./s1
InChI key
HFJFXXDHVWLIKX-YDALLXLXSA-N
基因信息
human ... DRD2(1813)
应用
S-(-)-盐酸依替必利已用于星形胶质细胞-神经元共培养 和官能性磁共振成像 (fMRI) 实验。
生化/生理作用
强效和选择性 D2 多巴胺受体拮抗剂。依替必利对 DAD2 受体的特异性高于匹莫齐特或氟哌啶醇。编码D2多巴胺受体(DRD2)的基因与包括帕金森病在内的多种疾病、精神分裂症和酒精中毒易感性有关。
制备说明
溶液可在 4° C下储存数天
法律信息
经 Astra AB 许可生产和销售。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Dopaminergic imaging of nonmotor manifestations in a rat model of Parkinson's disease by fMRI
Neurobiology of Disease, 49(9), 99-106 (2013)
The dopamine D2 antagonist eticlopride accelerates extinction and delays reacquisition of food self-administration in rats
Behavioural Pharmacology, 24(8), 633-633 (2013)
Nature materials, 19(10), 1102-1109 (2020-06-17)
Biodegradable and biocompatible elastic materials for soft robotics, tissue engineering or stretchable electronics with good mechanical properties, tunability, modifiability or healing properties drive technological advance, and yet they are not durable under ambient conditions and do not combine all the
European journal of pharmacology, 120(2), 217-226 (1986-01-21)
The novel substituted benzamide eticlopride, (S)-(-)-5-chloro-3-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxy salicylamide hydrochloride (A38503; FLB 131), was radiolabelled to high specific activity and used for in vivo receptor binding studies in the rat brain. Intravenous injections of [3H]eticlopride resulted in a rapid accumulation of radioactivity
Ciliary neurotrophic factor mediates dopamine D2 receptor-induced CNS neurogenesis in adult mice
The Journal of Neuroscience, 28(9), 2231-2241 (2008)
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