E101
S-(−)-Eticlopride 盐酸盐
≥98% (HPLC), D2 dopamine receptor antagonist, powder
别名:
FLB 131, S-(−)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide 盐酸盐
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关于此项目
经验公式（希尔记法）:
C17H25ClN2O3 · HCl
化学文摘社编号:
分子量:
377.31
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
S-(−)-Eticlopride 盐酸盐, ≥98% (HPLC), powder
SMILES string
Cl.CCN1CCC[C@H]1CNC(=O)c2c(O)c(CC)cc(Cl)c2OC
InChI key
HFJFXXDHVWLIKX-YDALLXLXSA-N
InChI
1S/C17H25ClN2O3.ClH/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2;/h9,12,21H,4-8,10H2,1-3H3,(H,19,22);1H/t12-;/m0./s1
assay
≥98% (HPLC)
form
powder
optical activity
[α]27/D −7.2°, c = 0.3 in methanol(lit.)
storage condition
desiccated
color
off-white
solubility
H2O: soluble >10 mg/mL
ethanol: soluble 2.6 mg/mL
0.1 M HCl: soluble 7 mg/mL
Quality Level
Gene Information
human ... DRD2(1813)
相关类别
Application
S-(-)-盐酸依替必利已用于星形胶质细胞-神经元共培养 和官能性磁共振成像 (fMRI) 实验。
Biochem/physiol Actions
强效和选择性 D2 多巴胺受体拮抗剂。依替必利对 DAD2 受体的特异性高于匹莫齐特或氟哌啶醇。编码D2多巴胺受体（DRD2）的基因与包括帕金森病在内的多种疾病、精神分裂症和酒精中毒易感性有关。
Legal Information
经 Astra AB 许可生产和销售。
Preparation Note
溶液可在 4° C下储存数天
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Ciliary neurotrophic factor mediates dopamine D2 receptor-induced CNS neurogenesis in adult mice
Yang P, et al.
The Journal of Neuroscience, 28(9), 2231-2241 (2008)
The dopamine D2 antagonist eticlopride accelerates extinction and delays reacquisition of food self-administration in rats
Koerber J, et al.
Behavioural Pharmacology, 24(8), 633-633 (2013)
C Köhler et al.
European journal of pharmacology, 120(2), 217-226 (1986-01-21)
The novel substituted benzamide eticlopride, (S)-(-)-5-chloro-3-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxy salicylamide hydrochloride (A38503; FLB 131), was radiolabelled to high specific activity and used for in vivo receptor binding studies in the rat brain. Intravenous injections of [3H]eticlopride resulted in a rapid accumulation of radioactivity
Melanie Baumgartner et al.
Nature materials, 19(10), 1102-1109 (2020-06-17)
Biodegradable and biocompatible elastic materials for soft robotics, tissue engineering or stretchable electronics with good mechanical properties, tunability, modifiability or healing properties drive technological advance, and yet they are not durable under ambient conditions and do not combine all the
Dopaminergic imaging of nonmotor manifestations in a rat model of Parkinson's disease by fMRI
Chen C C V, et al.
Neurobiology of Disease, 49(9), 99-106 (2013)
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