E006
EDDP 高氯酸盐
Benzodiazepine receptor inverse agonist, solid
别名:
β-CCA methylamide, FG-7142, N-Methyl-β-carboline-3-carboxamide
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关于此项目
经验公式（希尔记法）:
C13H11N3O
化学文摘社编号:
分子量:
225.25
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
产品名称
EDDP 高氯酸盐,
SMILES string
CNC(=O)c1cc2c(cn1)[nH]c3ccccc23
InChI
1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17)
InChI key
QMCOPDWHWYSJSA-UHFFFAOYSA-N
form
solid
color
light tan
solubility
DMSO: >10 mg/mL
H2O: insoluble
Quality Level
Gene Information
human ... BZRAP1(9256)
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相关类别
Disclaimer
Solutions may be stored for several days at 4 °C.
Biochem/physiol Actions
Benzodiazepine inverse receptor agonist; potent anxiogenic agent.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Andrew R Delamater et al.
Journal of experimental psychology. Animal behavior processes, 35(2), 224-237 (2009-04-15)
Previous research has reported a role for the neurotransmitter gamma-aminobutyric acid (GABA) in the extinction and renewal of conditioned fear. Here, the authors examine whether GABA is involved in the acquisition, extinction, renewal, spontaneous recovery, and latent inhibition of appetitive
Jodi L Lukkes et al.
Brain research, 1443, 1-17 (2012-02-03)
Our previous studies have shown that post-weaning social isolation of male rats leads to sensitization of serotonergic systems and increases in anxiety-like behavior in adulthood. Although studies in humans suggest that females have an increased sensitivity to stress and risk
Matthew W Hale et al.
Progress in neuro-psychopharmacology & biological psychiatry, 34(7), 1285-1293 (2010-07-22)
The basolateral amygdala is a nodal structure within a distributed and interconnected network that regulates anxiety states and anxiety-related behavior. Administration of multiple anxiogenic drugs increases cellular responses (i.e., increases c-Fos expression) in a subregion of the basolateral amygdala, but
Sarah I Martire et al.
Behavioural brain research, 209(1), 131-136 (2010-02-02)
Three experiments used intake, clusters, and licks per cluster to study the effects of the GABA inverse agonist, FG 7142, on sensory-specific satiety in rats. In Experiment 1, rats were offered one of two palatable solutions and 30min later tested
Kwok Ho C Choy et al.
Psychopharmacology, 221(4), 649-657 (2011-12-24)
Vigilant scanning of the environment is a major risk assessment activity in many species. However, due to difficulties in its manual scoring, scanning has rarely been quantified in laboratory rodent studies. We developed a novel method for automated measurement of
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