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Merck
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文件

D9766

Sigma-Aldrich

双嘧达莫

≥98% (HPLC), powder, phosphodiesterase V inhibitor

别名:

NSC 515776, NSC 619103

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About This Item

经验公式（希尔记法）:
C24H40N8O4
CAS号:
58-32-2
分子量:
504.63
EC 号:
200-374-7
MDL编号:
MFCD00010555
UNSPSC代码:
41106305
PubChem化学物质编号:
24277705
NACRES:
NA.77

product name

双嘧达莫, ≥98% (HPLC)

质量水平

200

检测方案

≥98% (HPLC)

形式

powder

颜色

yellow

mp

165-166 °C (lit.)

溶解性

DMSO: soluble
ethanol: soluble

创始人

Boehringer Ingelheim

储存温度

room temp

SMILES字符串

OCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO

InChI

1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2

InChI key

IZEKFCXSFNUWAM-UHFFFAOYSA-N

基因信息

human ... CYP1A2(1544) , PDE10A(10846) , PDE1A(5136) , PDE1B(5153) , PDE1C(5137) , PDE2A(5138) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE5A(8654) , PDE6A(5145) , PDE6B(5158) , PDE6C(5146) , PDE6D(5147) , PDE6G(5148) , PDE6H(5149) , PDE7A(5150) , PDE7B(27115) , PDE8A(5151) , PDE8B(8622) , PDE9A(5152) , SLC29A1(2030)
mouse ... Slc29a1(63959)

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一般描述

双嘧达莫阻止细胞摄取腺苷。作为一种平衡核苷转运蛋白 1 (ENT1) 抑制剂发挥作用。

应用

双嘧达莫已用于：
  • 进行体外生长抑制试验 (40)
  • 测定其预防子宫肌层收缩的能力 (41)
  • 确定其对烟酰胺腺嘌呤二核苷酸 (NAD +) 诱导的细胞内三磷酸腺苷 (ATP) 水平增加的作用 (42)
  • ，防止烟酰胺核苷 (NR) 诱导的轴突保护作用 (43)

生化/生理作用

磷酸二酯酶 V 选择性抑制剂 (PDE 5)；强效冠脉扩张药物；腺苷转运抑制剂；血小板聚集抑制剂。

特点和优势

该化合物是受体分类及信号转导手册上磷酸二酯酶页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
该化合物由 Boehringer Ingelheim 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Jiwen Li et al.
The Journal of experimental medicine, 218(6) (2021-04-24)
Previous studies implicated the neuronal guidance molecule netrin-1 in attenuating myocardial ischemia-reperfusion injury. However, the tissue-specific sources and receptor signaling events remain elusive. Neutrophils are among the first cells responding to an ischemic insult and can be associated with tissue
Terence B Beghyn et al.
Journal of medicinal chemistry, 54(9), 3222-3240 (2011-04-21)
The dominant strategy for discovery of new antimalarial drugs relies on cell-free assays on specific biochemical pathways of Plasmodium falciparum . However, it appears that screening directly on the parasite is a more rewarding approach. The "drug to genome to
Extracellular Degradation into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD+-produced increases in the Adenylate Pool of BV2 Microglia under Basal Conditions
Zhang J, et al.
Frontiers in Cellular Neuroscience, 12 (2018)
J A Thorn et al.
General pharmacology, 27(4), 613-620 (1996-06-01)
1. In mammals, nucleoside transport is an important determinant of the pharmacokinetics, plasma and tissue concentration, disposition and in vivo biological activity of adenosine as well as nucleoside analogues used in antiviral and anticancer therapies. 2. Two broad types of
Nyoli Valentine et al.
The Cochrane database of systematic reviews, 11, CD005449-CD005449 (2012-11-16)
Cardiovascular disease (CVD) is the most prevalent complication of type 2 diabetes with an estimated 65% of people with type 2 diabetes dying from a cause related to atherosclerosis. Adenosine-diphosphate (ADP) receptor antagonists like clopidogrel, ticlopidine, prasugrel and ticagrelor impair
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