D7409
2′,3′-双脱氧鸟苷 5′-三磷酸 钠盐
≥90% (HPLC)
别名:
ddGTP
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关于此项目
经验公式（希尔记法）:
C10H16N5O12P3
化学文摘社编号:
分子量:
491.18
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
产品名称
2′,3′-双脱氧鸟苷 5′-三磷酸 钠盐, ≥90% (HPLC)
InChI
1S/C10H16N5O12P3.Na/c11-10-13-8-7(9(16)14-10)12-4-15(8)6-2-1-5(25-6)3-24-29(20,21)27-30(22,23)26-28(17,18)19;/h4-6H,1-3H2,(H,20,21)(H,22,23)(H2,17,18,19)(H3,11,13,14,16);/q;+1/p-1/t5-,6+;/m0./s1
SMILES string
[Na+].OP([O-])(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]1CC[C@@H](O1)n2cnc3C(=O)NC(=N)Nc23
InChI key
XCOBCPBPAINELA-RIHPBJNCSA-M
assay
≥90% (HPLC)
form
powder
solubility
water: 5 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
Gene Information
human ... HRAS(3265)
相关类别
Application
2′,3′-二脱氧鸟苷 5′-三磷酸（ddGTP） 用作链终止剂抑制剂和端粒酶抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Z Debyser et al.
The Journal of biological chemistry, 267(17), 11769-11776 (1992-06-15)
Recently, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione (TIBO) and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) compounds have been shown to be potent, selective, and specific inhibitors of human immunodeficiency virus type 1 (HIV-1) replication in vitro. They interact with the reverse transcriptase of HIV-1 in a way
Nathan A Tanner et al.
Nucleic acids research, 37(4), e27-e27 (2009-01-22)
We present a simple technique for visualizing replication of individual DNA molecules in real time. By attaching a rolling-circle substrate to a TIRF microscope-mounted flow chamber, we are able to monitor the progression of single-DNA synthesis events and accurately measure
H Zhang et al.
Antiviral research, 24(1), 43-57 (1994-05-01)
Two mutants of HIV-1 reverse transcriptase (RT), Tyr-188-->His and Glu-138-->Arg have been prepared and their catalytic properties and sensitivities to inhibitors studied. As compared to wild type RT, a reduction in catalytic efficiency and turn over number was observed, especially
H Jonckheere et al.
The Journal of biological chemistry, 269(41), 25255-25258 (1994-10-14)
Determination of the three-dimensional structure of the human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) has indicated a totally different folding for the 51-kDa subunit (p51) than for the 66-kDa subunit (p66). The polymerase catalytic site is located on the
H Pelemans et al.
Molecular pharmacology, 57(5), 954-960 (2000-04-25)
Trp-229 is part of the non-nucleoside reverse transcriptase inhibitor (NNRTI)-binding pocket of HIV type 1 (HIV-1) reverse transcriptase (RT), and is also part of the "primer grip" of HIV-1 RT. Using site-directed mutagenesis, seven RT mutants were constructed bearing the
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