所有图片(1)
About This Item
经验公式（希尔记法）:
C10H13N5O2
CAS号:
分子量:
235.24
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥95% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: soluble
储存温度
−20°C
SMILES字符串
C[C@H]1O[C@H](C[C@@H]1O)n2cnc3c(N)ncnc23
InChI
1S/C10H13N5O2/c1-5-6(16)2-7(17-5)15-4-14-8-9(11)12-3-13-10(8)15/h3-7,16H,2H2,1H3,(H2,11,12,13)/t5-,6+,7-/m1/s1
InChI key
FFHPXOJTVQDVMO-DSYKOEDSSA-N
基因信息
rat ... Adcy2(81636)
应用
2′,5′-Dideoxyadenosine has been used to elucidate the mechanism of diligustilide (DLG). It has also been used to inhibit adenylate cyclase (AC).
生化/生理作用
Cell-permeable adenylyl cyclase inhibitor. IC50 = 2.7 μM in detergent-dispersed rat brain preparations.
特点和优势
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
重悬
Store at −20 °C after reconstitution.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Gastroprotective effect of diligustilide isolated from roots of Ligusticum porteri coulter & rose (Apiaceae) on ethanol-induced lesions in rats
Velazquez-Moyado J, et al.
Journal of Ethnopharmacology, 174, 403-409 (2015)
Yukihisa Matsumoto et al.
PloS one, 8(7), e68538-e68538 (2013-07-31)
Many insects exhibit excellent capability of visual learning, but the molecular and neural mechanisms are poorly understood. This is in contrast to accumulation of information on molecular and neural mechanisms of olfactory learning in insects. In olfactory learning in insects
Rula Azzam et al.
AIDS research and human retroviruses, 22(7), 619-629 (2006-07-13)
HIV-1 infection of cells of macrophage lineage impairs a number of effector functions performed by these cells, including phagocytosis of opsonized pathogens. In this study we investigate the effects of HIV-1 on the mechanism of complement (C')-mediated phagocytosis by human
Fen Hu et al.
Molecular medicine reports, 24(4) (2021-07-31)
Inflammation and oxidative stress have indispensable roles in the development of acute lung injury (ALI). MicroRNA (miRNA/miR)‑351‑5p was initially identified as a myogenesis‑associated miRNA; however, its role in lipopolysaccharide (LPS)‑induced ALI remains unclear. The aim of the present study was
Akira Ikari et al.
Journal of cell science, 119(Pt 9), 1781-1789 (2006-04-13)
Although paracellin-1 (PCLN-1) is known to have a crucial role in the control of Mg2+ reabsorption in the kidney, the molecular pathways involved in the regulation of PCLN-1 have not been clarified. We used FLAG-tagged PCLN-1 to investigate these pathways
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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