D7408
2′,5′-Dideoxyadenosine
≥95% (HPLC), Adenylyl cyclase inhibitor, solid
别名:
2ʹ,5ʹ-dd-Ado, NSC 95943
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关于此项目
经验公式（希尔记法）:
C10H13N5O2
化学文摘社编号:
分子量:
235.24
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
产品名称
2′,5′-Dideoxyadenosine, ≥95% (HPLC), solid
SMILES string
C[C@H]1O[C@H](C[C@@H]1O)n2cnc3c(N)ncnc23
InChI key
FFHPXOJTVQDVMO-DSYKOEDSSA-N
InChI
1S/C10H13N5O2/c1-5-6(16)2-7(17-5)15-4-14-8-9(11)12-3-13-10(8)15/h3-7,16H,2H2,1H3,(H2,11,12,13)/t5-,6+,7-/m1/s1
assay
≥95% (HPLC)
form
solid
color
white
solubility
DMSO: soluble
storage temp.
−20°C
Quality Level
Gene Information
rat ... Adcy2(81636)
Application
2′,5′-Dideoxyadenosine has been used to elucidate the mechanism of diligustilide (DLG). It has also been used to inhibit adenylate cyclase (AC).
Biochem/physiol Actions
Cell-permeable adenylyl cyclase inhibitor. IC50 = 2.7 μM in detergent-dispersed rat brain preparations.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
Store at −20 °C after reconstitution.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Inflammation and oxidative stress have indispensable roles in the development of acute lung injury (ALI). MicroRNA (miRNA/miR)‑351‑5p was initially identified as a myogenesis‑associated miRNA; however, its role in lipopolysaccharide (LPS)‑induced ALI remains unclear. The aim of the present study was
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Velazquez-Moyado J, et al.
Journal of Ethnopharmacology, 174, 403-409 (2015)
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PloS one, 8(7), e68538-e68538 (2013-07-31)
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商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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