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Merck
CN

D7017

Dynorphin A Porcine Fragment 1-13

≥97% (HPLC)

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关于此项目

经验公式（希尔记法）:
C75H126N24O15
化学文摘社编号:
72957-38-1
分子量:
1603.95
NACRES:
NA.32
PubChem Substance ID:
24894071
UNSPSC Code:
12352202
MDL number:
MFCD00076366

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form

powder

InChI

1S/C75H126N24O15/c1-7-45(6)61(70(111)94-53(25-17-35-87-75(83)84)71(112)99-36-18-26-58(99)69(110)93-50(21-11-13-31-76)64(105)96-56(38-44(4)5)67(108)95-54(72(113)114)22-12-14-32-77)98-65(106)52(24-16-34-86-74(81)82)91-63(104)51(23-15-33-85-73(79)80)92-66(107)55(37-43(2)3)97-68(109)57(40-46-19-9-8-10-20-46)90-60(102)42-88-59(101)41-89-62(103)49(78)39-47-27-29-48(100)30-28-47/h8-10,19-20,27-30,43-45,49-58,61,100H,7,11-18,21-26,31-42,76-78H2,1-6H3,(H,88,101)(H,89,103)(H,90,102)(H,91,104)(H,92,107)(H,93,110)(H,94,111)(H,95,108)(H,96,105)(H,97,109)(H,98,106)(H,113,114)(H4,79,80,85)(H4,81,82,86)(H4,83,84,87)

SMILES string

CCC(C)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc2ccc(O)cc2)C(=O)NC(CCCNC(N)=N)C(=O)N3CCCC3C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(O)=O

InChI key

OVVIBUHLQIYUEU-UHFFFAOYSA-N

assay

≥97% (HPLC)

composition

Peptide content, ≥50%

UniProt accession no.

P01214

storage temp.

−20°C

Quality Level

200

Gene Information

pig ... PDYN(445529)

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Application

Dynorphin A Porcine Fragment 1-13 has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS).

Biochem/physiol Actions

Dynorphin (Dyn) (1-13), a bioactive product of dynorphin A displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors. It elevates intracellular calcium [Ca2+]i level and contributes to the loss of neurons affecting neuronal viability.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000518010
0000518010
SLCN5933
SLCJ5025
SLBV4020

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Xin Sun et al.
Life sciences, 78(21), 2516-2522 (2005-12-13)
To investigate the relaxation effect and underlying mechanism of U50,488H (a selective kappa-opioid receptor agonist) in pulmonary artery in the rat. Isolated pulmonary artery ring was perfused and the tension of the vessel was measured. U50,488H relaxed the pulmonary artery
Sylvie Tordjman et al.
Behavior genetics, 33(5), 529-536 (2003-10-24)
Previous studies suggest that brain opioid activity decreases aggression in animal models. The main objective of the current study was to examine the possible genetic relationship between intermale aggression and brain levels of enkephalins, endorphins, and dynorphins in 11 inbred
Jing Liang et al.
Neuropharmacology, 58(1), 233-240 (2009-07-15)
Our previous studies have demonstrated that morphine-induced conditioned place preference (CPP) can be inhibited by 2 Hz electroacupuncture (EA). This inhibition can be blocked by either the opioid receptor antagonist naloxone (i.p.) or lesion in the nucleus accumbens (NAc), providing
B Brugos et al.
Die Pharmazie, 59(5), 339-343 (2004-06-24)
Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of
M Hiramatsu et al.
Methods and findings in experimental and clinical pharmacology, 20(7), 595-599 (1998-11-20)
The role of kappa-opioid receptor agonists on learning and memory is controversial. In this review, the effects of dynorphin A (1-13) and U-50,488H on learning and memory impairments in mice and rats are summarized. Muscarinic cholinergic antagonists and a nicotinic
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