所有图片(4)
别名:
11-去氧皮质酮乙酸酯, 21-乙酰氧基孕甾-4-烯-3,20-二酮, 21-羟基孕甾-4-烯-3,20-二酮-21-醋酸酯, 21-羟基孕酮-21-乙酸酯, DOC 乙酸酯, 乙酸脱氧肾上腺皮质固酮, 孕甾-4-烯-21-醇-3,20-二酮-21-醋酸酯, 脱氧皮质酮醋酸酯
经验公式（希尔记法）:
C23H32O4
CAS号:
分子量:
372.50
Beilstein:
2570798
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
生物来源
synthetic (organic)
质量水平
无菌性
non-sterile
检测方案
≥98% (HPLC)
形式
powder
溶解性
H2O: insoluble
acetone: soluble (1 in 30)
alcohol: soluble (1 in 50)
chloroform: freely soluble
dioxane: slightly soluble
vegetable oils: slightly soluble
运输
ambient
储存温度
room temp
SMILES字符串
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O
InChI
1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1
InChI key
VPGRYOFKCNULNK-ACXQXYJUSA-N
基因信息
human ... NR3C2(4306)
正在寻找类似产品? 访问 产品对比指南
一般描述
Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one.
应用
Deoxycorticosterone acetate has been used to induce hypertensive pregnancy. It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
WGK
WGK 3
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
Douglas Jackson et al.
Molecules (Basel, Switzerland), 23(7) (2018-06-23)
(−)-Epicatechin (E) is a flavanol found in green tea and cocoa and has been shown to attenuate tumour necrosis factor alpha (TNF-α)-mediated inflammation, improve nitric oxide levels, promote endothelial nitric oxide synthase (eNOS) activation and inhibit NADPH oxidase. This study
(-)-Epicatechin Reduces Blood Pressure and Improves Left Ventricular Function and Compliance in Deoxycorticosterone Acetate-Salt Hypertensive Rats
Jackson D, et al.
Molecules (Basel), 23(7), 1511-1511 (2018)
The mislabelling of deoxycorticosterone: making sense of corticosteroid structure and function.
Vinson GP
The Journal of Endocrinology, 211(1), 3-16 (2011)
Placental nitric oxide formation and endothelium-dependent vasodilation underlie pravastatin effects against angiogenic imbalance, hypertension in pregnancy and intrauterine growth restriction
Chimini JS, et al.
Basic and Clinical Pharmacology and Toxicology (2018)
Rafael Soares Lindoso et al.
Molecular therapy. Methods & clinical development, 16, 63-77 (2019-12-25)
Hypertension is a long-term condition that can increase organ susceptibility to insults and lead to severe complications such as chronic kidney disease (CKD). Extracellular vesicles (EVs) are cell-derived membrane structures that participate in cell-cell communication by exporting encapsulated molecules to
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门