D5412
2′-脱氧尿苷
≥98.5%, synthetic (organic), powder
别名:
1-(2-脱氧-β-D-呋喃核糖基）尿嘧啶, 尿嘧啶脱氧核苷
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关于此项目
经验公式（希尔记法）:
C9H12N2O5
化学文摘社编号:
分子量:
228.20
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
213-455-7
MDL number:
Beilstein/REAXYS Number:
24433
产品名称
2′-脱氧尿苷, ≥98.5%
InChI key
MXHRCPNRJAMMIM-SHYZEUOFSA-N
InChI
1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1
SMILES string
OC[C@H]1O[C@H](C[C@@H]1O)N2C=CC(=O)NC2=O
biological source
synthetic (organic)
assay
≥98.5%
form
powder
impurities
Thymidine, free
solubility
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
Quality Level
Gene Information
mouse ... Slc29a1(63959)
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Application
2′-脱氧尿苷已用于：
- 代替胸苷用作[3H]胸苷三磷酸 (TTP)前体，避免在相对增殖测定中潜在的胸苷阻断
- 用作核苷补充剂，以进行细胞周期同步和DNA复制抑制
- 用作培养基中的有丝分裂抑制剂，最大限度减少神经胶质细胞增殖
Biochem/physiol Actions
2′-脱氧尿苷(dU)经常被卤化，生成用于DNA合成和降解机制研究的胸苷激酶类似物。作为标记底物的衍生2′-脱氧尿苷包括氯-2′-脱氧尿苷(CldU)、溴脱氧尿苷(BrdU)和/或碘脱氧尿苷(IdU)。其他有用的2′-脱氧尿苷类似物包括5-乙基-2′-脱氧尿苷(DdU)和5-羟基甲基-2′-脱氧尿苷(HmdU)。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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