生物来源
synthetic (organic)
质量水平
检测方案
≥98.5%
形式
powder
杂质
Thymidine, free
溶解性
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
SMILES字符串
OC[C@H]1O[C@H](C[C@@H]1O)N2C=CC(=O)NC2=O
InChI
1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1
InChI key
MXHRCPNRJAMMIM-SHYZEUOFSA-N
基因信息
mouse ... Slc29a1(63959)
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应用
2′-脱氧尿苷已用于：
- 代替胸苷用作[3H]胸苷三磷酸 (TTP)前体，避免在相对增殖测定中潜在的胸苷阻断
- 用作核苷补充剂，以进行细胞周期同步和DNA复制抑制
- 用作培养基中的有丝分裂抑制剂，最大限度减少神经胶质细胞增殖
生化/生理作用
2′-脱氧尿苷(dU)经常被卤化，生成用于DNA合成和降解机制研究的胸苷激酶类似物。作为标记底物的衍生2′-脱氧尿苷包括氯-2′-脱氧尿苷(CldU)、溴脱氧尿苷(BrdU)和/或碘脱氧尿苷(IdU)。其他有用的2′-脱氧尿苷类似物包括5-乙基-2′-脱氧尿苷(DdU)和5-羟基甲基-2′-脱氧尿苷(HmdU)。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Kaori Nomura-Komoike et al.
Scientific reports, 10(1), 1488-1488 (2020-02-01)
Müller glia, the principal glial cell type in the retina, have the potential to reenter the cell cycle after retinal injury. In mammals, proliferation of Müller glia is followed by gliosis, but not regeneration of neurons. Retinal injury is also
Quan-Liang Jian et al.
PeerJ, 6, e5739-e5739 (2018-10-09)
Both age and intensive exercise are generally considered critical risk factors for osteoarthritis. In this work, we intend to establish zebrafish models to assess the role of these two factors on cartilage homeostasis. We designed a swimming device for zebrafish
Yang Yang et al.
Cancer letters, 453, 170-183 (2019-04-08)
Overexpression of NQO1 is associated with poor prognosis in human cancers including lung, stomach, colon, cervical, and pancreatic cancers. However, the molecular mechanisms underlying the protumorigenic capacities of NQO1 have not been fully elucidated. Here, we investigated this question and
Yingqiao Wang et al.
ACS nano, 15(9), 14662-14671 (2021-08-26)
Understanding cellular electrical communications in both health and disease necessitates precise subcellular electrophysiological modulation. Nanomaterial-assisted photothermal stimulation was demonstrated to modulate cellular activity with high spatiotemporal resolution. Ideal candidates for such an application are expected to have high absorbance at
Gabriel Robert et al.
Chemical research in toxicology, 33(2), 565-575 (2019-12-11)
The reaction of hydroxyl radical (HO•) with thymine in DNA generates 5-(uracilyl)-methyl radicals (T•) and the corresponding methylperoxyl radical (TOO•) in the presence of O2, which in turn propagates damage by reacting with a vicinal nucleobase. This leads to so-called
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