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Merck
CN
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文件

D4628

Sigma-Aldrich

己烯雌酚

≥99% (HPLC)

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别名:
(E)-3,4-双(4-羟苯基)3-亚己基, DES, 乙芪酚
经验公式（希尔记法）:
C18H20O2
CAS号:
56-53-1
分子量:
268.35
Beilstein:
2056095
EC 号:
200-278-5
MDL编号:
MFCD00002373
UNSPSC代码:
51111800
PubChem化学物质编号:
24893887
NACRES:
NA.77

质量水平

200

检测方案

≥99% (HPLC)

形式

powder

SMILES字符串

CC\C(c1ccc(O)cc1)=C(\CC)c2ccc(O)cc2

InChI

1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+

InChI key

RGLYKWWBQGJZGM-ISLYRVAYSA-N

基因信息

human ... ESR1(2099) , ESR2(2100) , ESRRG(2104)
mouse ... Esr1(13982)
rat ... Ar(24208) , Esr1(24890)

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应用

己烯雌酚已用于:
  • 通过定量测定内源性雌激素调节的标记基因的表达水平来评估己烯雌酚的雌激素活性
  • 在生物发光酵母生物报告基因检测试（ bioluminescent yeast bioreporter assay，BLYES）中评估雌激素、雄激素和毒性反应
  • 检测其对黑素细胞增殖和酪氨酸酶活性的影响

生化/生理作用

己烯雌酚是一种具有致癌性质的合成雌激素。它能导致叙利亚仓鼠患肾透明细胞癌。它能导致人类患乳腺癌、阴道和宫颈的透明细胞腺癌（CCA）以及生殖异常的风险增加。可用于治疗前列腺癌，阻止睾酮的产生。

警示用语：

Danger

危险分类

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Screening of potentially hormonally active chemicals using bioluminescent yeast bioreporters
Sanseverino J, et al.
Toxicological Sciences, 107(1), 122-134 (2008)
Assaying estrogenicity by quantitating the expression levels of endogenous estrogen-regulated genes.
Jorgensen M, et al.
Environmental Health Perspectives, 108(5), 403-403 (2000)
Pierre-Olivier Bosset et al.
BJU international, 110(11 Pt C), E826-E829 (2012-05-15)
What's known on the subject? and What does the study add? Diethylstilbestrol (DES) has been found to have anti-tumour properties and clinical effectiveness in prostate cancer that is resistant to the first-line hormonal therapy. This review found that low-dose DES
Hanna K L Johansson et al.
Reproductive toxicology (Elmsford, N.Y.), 101, 9-17 (2021-02-12)
Developmental exposure to endocrine disrupting chemicals can have negative consequences for reproductive health in both men and women. Our knowledge about how chemicals can cause adverse health outcomes in females is, however, poorer than our knowledge in males. This is
Aimee A D'Aloisio et al.
Epidemiology (Cambridge, Mass.), 24(2), 277-284 (2013-01-26)
Early menarche is related to increased risk of breast cancer. The number of established factors that contribute to early menarche is limited. We studied prenatal and infant exposures in relation to age at menarche in a nationwide cohort of women
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