所有图片(1)
About This Item
经验公式（希尔记法）:
C8H9NO4 · xH2O
CAS号:
分子量:
183.16 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
protect from light
颜色
white
储存温度
−20°C
SMILES字符串
O.N[C@H](C(O)=O)c1cc(O)cc(O)c1
InChI
1S/C8H9NO4.H2O/c9-7(8(12)13)4-1-5(10)3-6(11)2-4;/h1-3,7,10-11H,9H2,(H,12,13);1H2/t7-;/m0./s1
InChI key
QZEFIWWBQUKNFA-FJXQXJEOSA-N
基因信息
human ... GRM1(2911)
应用
(S)-3,5-二羟基苯基甘氨酸水合物已被用于：
- 作为mGluR1/5激动剂，在突触神经小体的制备中激活代谢型谷氨酸受体1 (mGluR1/5)
- 用于人工脑脊液 (ACSF) 的DHPG激活
- 注入基底外侧杏仁核，研究其对记忆表达的影响
生化/生理作用
（S）-3，5-二羟基苯基甘氨酸水合物是 I 类代谢型谷氨酸受体激动剂。
特点和优势
该化合物是受体分类及信号转导手册上谷氨酸受体（G蛋白家族）页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
注意
空气敏感
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Infantile amnesia reflects a developmental critical period for hippocampal learning
Travaglia A, et al.
Nature Neuroscience, 19(9), 1225-1225 (2016)
Qin-Wei Wu et al.
Frontiers in cell and developmental biology, 8, 569889-569889 (2021-02-09)
Spinocerebellar ataxias (SCAs) are a group of hereditary neurodegenerative diseases which are caused by diverse genetic mutations in a variety of different genes. We have identified RGS8, a regulator of G-protein signaling, as one of the genes which are dysregulated
Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome
Thomson SR, et al.
Neuron, 95(3), 550-563 (2017)
Overexpression of STIM1 in neurons in mouse brain improves contextual learning and impairs long-term depression
Majewski L, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1864(6), 1071-1087 (2017)
Enoch Ng et al.
Behavioural brain research, 381, 112420-112420 (2019-12-11)
Neuronal calcium sensor-1 or Frequenin is a calcium sensor widely expressed in the nervous system, with roles in neurotransmission, neurite outgrowth, synaptic plasticity, learning, and motivated behaviours. Neuronal calcium sensor-1 has been implicated in neuropsychiatric disorders including autism spectrum disorder
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